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7 publications mentioning aae-mir-1

Open access articles that are associated with the species Aedes aegypti and mention the gene name mir-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 14
Deep sequencing data revealed that in the nucleus of mosquito cells infected with Wolbachia, the expression of miR-1, miR-10 and miR263a-3p was suppressed and 11 other miRNAs were induced; miR-9a, miR-12-3p, miR-124, miR-125-5p, miR-282-5p, miR-308-5p, miR-932-3p, miR-965, miR-988-5p, miR-1000 and miR-1175-5p (Figure 8A). [score:5]
miR-11-5p, miR92a-5p, miR-932-3p, miR-965, miR-988-5p and miR1175-5p were expressed in the nucleus and 11 in the cytoplasm: miR-1, miR-10, miR-22, miR-79-3p, miR-137, miR-219, miR-263a-3p, miR-285, miR-286b, miR-1174 and miR-1175 (Figure 3B; Table S1). [score:3]
In the cytoplasm, miR-11-5p, miR-92a-5p, miR-210, miR-932-5p and miR-1175-5p were suppressed and 14 miRNAs were induced; miR-1, miR-9a, miR-12-3p, miR-33, miR-34-3p, miR-79-3p, miR-124, miR-219, miR-252-5p, miR-286b, miR308-5p, miR-1000, miR-1889-3p and miR-1890 (Figure 8B). [score:3]
Opposite to that, miR-1 was found in the nucleus in uninfected cells, but in Wolbachia-infected cells we could only find it in the cytoplasm (Figure 3A, B). [score:1]
Fifty seven miRNAs were found in both compartments, but miR-1, miR-34-3p, miR-252-5p, miR-1889-3p and miR-1890 were detected only in the nucleus; nine other miRNAs were detected solely in the cytoplasm; miR-125-5p, miR-137, miR-210, miR-282-5p, miR-285, miR-932-5p, miR-1174, miR-1175-3p and miR-1175-5p (Figure 3A). [score:1]
It seems possible that miR-1 is one of those miRNAs that is loaded onto AGO1 in the cytoplasm and transported to the nucleus mediated by importin β-4; blocking the distribution of AGO1 to the nucleus by Wolbachia explains why this miRNA was not detected in the nucleus of infected cells. [score:1]
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2
[+] score: 6
KUN-miR1 is 21nt in size and its expression is Dcr1 -dependent. [score:3]
This strongly resembles KUN-miRNA1, a viral small RNA expressed in mosquito cells infected with West Nile virus, a related flavivirus [70]. [score:3]
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3
[+] score: 4
For example, miR-315 and miR-8 regulate components of the Wg pathway, while miR-1 and miR-7 regulate N pathway components during fly development (reviewed by [136]). [score:4]
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4
[+] score: 4
recognition sites Mean MFE (Kcal/Mol) Recognition site start position on lincRNA_1317 miR-278-5p 5 -22.40 307, 749, 1112, 1260, 1491 miR-252-3p 4 -21.15 162, 629, 1560, 3946 miR-11-5p 3 -21.67 2248, 2286, 3328 miR-1890 3 -21.17 1489, 2712, 3602 miR-263a-3p 3 -21.47 2208, 2545, 3336 miR-33 3 -24.90 1545, 1810, 2669 miR-34-5p 3 -25.03 1020, 1232, 1379 miR-9b 3 -24.03 2034, 2891, 3603 let-7 2 -22.20 2747, 2817 miR-1 2 -22.80 1165, 2528 miR-1175-3p 2 -20.65 1489, 3274 miR-12-5p 2 -25.60 632, 1575 miR-1889-3p 2 -20.80 1268, 3988 miR-1891 2 -21.10 162, 2349 miR-282-5p 2 -25.70 1232, 1297 miR-2944b-3p 2 -22.05 1255, 3797 miR-2945-5p 2 -23.00 770, 1209 miR-31 2 -25.70 819, 871 miR-375 2 -22.25 66, 3293 miR-92b-5p 2 -23.05 1042, 3788 miR-9a 2 -20.65 170, 3500 We also used LncTar algorithm to predict any direct interaction between lincRNA_1317 and DENV-2 genome. [score:2]
recognition sites Mean MFE (Kcal/Mol) Recognition site start position on lincRNA_1317 miR-278-5p 5 -22.40 307, 749, 1112, 1260, 1491 miR-252-3p 4 -21.15 162, 629, 1560, 3946 miR-11-5p 3 -21.67 2248, 2286, 3328 miR-1890 3 -21.17 1489, 2712, 3602 miR-263a-3p 3 -21.47 2208, 2545, 3336 miR-33 3 -24.90 1545, 1810, 2669 miR-34-5p 3 -25.03 1020, 1232, 1379 miR-9b 3 -24.03 2034, 2891, 3603 let-7 2 -22.20 2747, 2817 miR-1 2 -22.80 1165, 2528 miR-1175-3p 2 -20.65 1489, 3274 miR-12-5p 2 -25.60 632, 1575 miR-1889-3p 2 -20.80 1268, 3988 miR-1891 2 -21.10 162, 2349 miR-282-5p 2 -25.70 1232, 1297 miR-2944b-3p 2 -22.05 1255, 3797 miR-2945-5p 2 -23.00 770, 1209 miR-31 2 -25.70 819, 871 miR-375 2 -22.25 66, 3293 miR-92b-5p 2 -23.05 1042, 3788 miR-9a 2 -20.65 170, 3500We also used LncTar algorithm to predict any direct interaction between lincRNA_1317 and DENV-2 genome. [score:2]
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5
[+] score: 1
The nine conserved miRNAs include let-7, miR-1, -133, -14, -184, -210, -9a, -970, and -998. [score:1]
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6
[+] score: 1
Only miRNAs aae-miR-2940-3p, which is mosquito specific, and aae-miR-1-5p were significantly enriched in ZIKV-infected libraries at this time point. [score:1]
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7
[+] score: 1
In some miRNAs such as miR-1, miR-11, miR-12 and miR-999 (miRNAs with probability index of 100%) the canonical sequences were the dominant isomiR in all situations (Fig. 7C). [score:1]
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