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miRBase |
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![]() 6 publications mentioning hsa-mir-1273cOpen access articles that are associated with the species Homo sapiens and mention the gene name mir-1273c. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: hsa-mir-1273h
Arrangement of the miR-1273 Family's Binding Sites in the mRNA of Target Genes.
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This analysis of the localization of paired miR-1273 binding sites in the mRNA of target genes leads to the conclusion that they evolved from a common ancestor.
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With a length of 22 nt, miR-1273c is coded in an intron of the T cell lymphoma invasion and metastasis 2 gene (TIAM2), located on chromosome 6. We found that 84 target gene mRNAs have one binding site for miR-1273c, while GOLGA3 has 2 sites, for a total of 86 miR-1273c sites.
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The adaptation of miRNA binding sites to each member of the miR-1273 family or to their combinations could also be due to the evolution of target gene mRNA and their varying functions.
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Such compactness in the binding site location of the miR-1273 family could be a result of embedding one general nucleotide sequence into the target genes.
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Some members of the miR-1273 family have a greater number of target genes than others.
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The distances described above between the pair binding sites of the miR-1273 family are nearly always matched in the target gene mRNA.
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The complementary nucleotide sequence to pre-miR-1273h includes binding sites for the miR-1273 family, and it is the most probable precursor for these segments (Figure 12).
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Members of the miR-1273 family have different origins, lengths, quantities, and properties of the miRNA binding sites, among other features.
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The location of paired miR-1273g-3p and miR-1273c binding sites is identical in both the mRNA 5′UTRs and the 3′UTRs (Figure 8).
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This study revealed that several hundred mRNAs have homologous nucleotide sequences containing binding sites for members of the miR-1273 family.
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The mRNAs of four genes have paired miR-1273g-3p and miR-1273c binding sites located in their 5′UTRs; two nucleotides are common to two sites (Figure 8).
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A feature of the miR-1273 family that this study discovered is the presence of pair binding sites in mRNA segments of 100 nucleotides.
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Features of the miR-1273 Family.
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Both miR-1273g-3p and miR-1273c have two overlapped nucleotides and pair binding sites, whose schemes are shown in Figure 8. The nucleotide sequences of miR-1273g-3p and miR-1273h have 16 overlapped nucleotides (Figure 12) that correspond to overlapping of their binding sites, shown in Figure 11.
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Arrangement of the Binding Sites of the miR-1273 Family in mRNA.
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However, all of the pair binding sites of the miR-1273 family have deviations of one-two nucleotides between them.
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Specifically, we examined pairs composed of miR-1273g-3p with another member of the miR-1273 family.
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Highly conserved binding sites of miR-1273 family in a large number of genes testify about their emergence in the early stages in human evolution.
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Other miRNAs from this paper: hsa-mir-125a, hsa-mir-34b, hsa-mir-511, hsa-mir-558, hsa-mir-567, hsa-mir-620, hsa-mir-644a, hsa-mir-543, hsa-mir-1234, hsa-mir-1302-7, hsa-mir-1303, hsa-mir-1277, hsa-mir-3166
Expression of miR-567 and miR-1273c was not detectable in colonic mucosae and colorectal cell lines (C [T]>36 cycles) (data not shown); whereas miR-1303 appeared to be fairly expressed in both normal and tumor colonic cells (Figure 5B).
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Our analysis allowed the identification of 3 MSI -targeted miRNAs: hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303.
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Note that hsa-mir-644 is included in the group of miRNAs rarely or not mutated in MSI CRCs (n = 18, frequency of mutation <25%) whereas hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303 constitute the group of miRNAs frequently altered (n = 3, frequency of mutation >75%).
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Note that hsa-mir-644 is incorporated in the group of miRNAs frequently altered, that also includes hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303 (n = 4, frequency of mutation >45%).
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A bi-allelic mutation was also noted in 36%, 57% and 83% of altered MSI CRC cell lines for mir-1273c, mir-567 or mir-1303, respectively (Figure 4, Table S2).
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MNR instabilities in hsa-mir-1273c (T11), hsa-mir-567 (A13) and hsa-mir-1303 (T13).
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The second group contained 3 miRNA genes (hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303) frequently mutated in MSI CRCs (≥75%).
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0031862.g004 Figure 4MNR instabilities in hsa-mir-1273c (T11), hsa-mir-567 (A13) and hsa-mir-1303 (T13).
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By screening the quasi totality of MNR and DNR (≥7 repeat units) contained in miRbase-V15-annotated miRNA hairpin sequences, hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567 were demonstrated to be mutated at high frequency in both CRC cell lines and primary tumors.
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Similar alterations were found in MSI primary tumors with the exception of hsa-mir-1273c, which generally displayed smaller levels of alterations in tumors (only 1 bp- deletion) (Figure 4, Table S2).
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-17, hsa-mir-21, hsa-mir-101-1, hsa-mir-30b, hsa-mir-144, hsa-mir-136, hsa-mir-101-2, hsa-mir-361, hsa-mir-374a, hsa-mir-376a-1, hsa-mir-423, hsa-mir-376b, hsa-mir-493, hsa-mir-495, hsa-mir-497, hsa-mir-500a, hsa-mir-376a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-625, hsa-mir-659, hsa-mir-1303, hsa-mir-1247, hsa-mir-1277, hsa-mir-664a, hsa-mir-1307, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-664b, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az
Besides, the newly detected 3p arms of hsa-mir-511-1, hsa-mir-511-2, hsa-mir-1273c and hsa-mir-1247 also have higher expression levels than the originally annotated 5p arm.
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-96, hsa-mir-182, hsa-mir-183, hsa-let-7g, hsa-let-7i, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-1301, hsa-mir-548e, hsa-mir-548j, hsa-mir-1285-1, hsa-mir-1285-2, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-1249, hsa-mir-1255a, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1255b-1, hsa-mir-1255b-2, hsa-mir-1306, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-5684, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-1273h, hsa-mir-548ba, hsa-mir-8078, hsa-mir-548bb, hsa-mir-548bc
A total of twelve miRNAs were found to be commonly regulated over time in these three tissues; let-7d, let-7e, miR-1249, miR-1254, miR-1255, miR-1273, miR-1285, miR-1301, miR-1306, miR-548, and miR-8078.
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Binding sites of the miR-1273 family, miR-1285-3p and miR-5684 in human mRNAs.
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-23a, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-105-1, hsa-mir-105-2, hsa-mir-129-1, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-204, hsa-mir-181a-1, hsa-mir-214, hsa-mir-222, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-30b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-129-2, hsa-mir-136, hsa-mir-320a, hsa-mir-181b-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-99b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-151a, hsa-mir-409, hsa-mir-181d, hsa-mir-92b, hsa-mir-663a, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-921, hsa-mir-663b, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-378b, hsa-mir-320e, hsa-mir-378c, hsa-mir-23c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-378j, hsa-mir-7704, hsa-mir-1273h
As demonstrated in Supplementary Table S1, five miRNAs belong to the hsa-miR-1273 family, which does not have well-documented anti-/pro-cancer properties, while among detected four members of the hsa-miR-30 family, hsa-miR-30c is reportedly involved promoting the invasiveness of metastatic breast cancer cells 11.
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7d, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-19a, hsa-mir-21, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-30a, hsa-mir-93, hsa-mir-16-2, hsa-mir-197, hsa-mir-148a, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-214, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-200b, hsa-mir-15b, hsa-mir-23b, hsa-mir-27b, hsa-mir-138-2, hsa-mir-142, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-146a, hsa-mir-150, hsa-mir-185, hsa-mir-106b, hsa-mir-29c, hsa-mir-299, hsa-mir-301a, hsa-mir-296, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-361, hsa-mir-365a, hsa-mir-374a, hsa-mir-377, hsa-mir-323a, hsa-mir-331, hsa-mir-339, hsa-mir-196b, hsa-mir-424, hsa-mir-18b, hsa-mir-20b, hsa-mir-483, hsa-mir-485, hsa-mir-486-1, hsa-mir-493, hsa-mir-496, hsa-mir-522, hsa-mir-92b, hsa-mir-550a-1, hsa-mir-550a-2, hsa-mir-647, hsa-mir-652, hsa-mir-550a-3, hsa-mir-675, hsa-mir-374b, hsa-mir-1255b-2, hsa-mir-2115, hsa-mir-3156-1, hsa-mir-3156-2, hsa-mir-3191, hsa-mir-3156-3, hsa-mir-2355, hsa-mir-3680-1, hsa-mir-374c, hsa-mir-550b-1, hsa-mir-550b-2, hsa-mir-4445, hsa-mir-4633, hsa-mir-4653, hsa-mir-4664, hsa-mir-4668, hsa-mir-4685, hsa-mir-4695, hsa-mir-4728, hsa-mir-4436b-1, hsa-mir-4787, hsa-mir-4804, hsa-mir-5002, hsa-mir-4436b-2, hsa-mir-3680-2, hsa-mir-5581, hsa-mir-486-2, hsa-mir-1273h
01720Xhsa-miR-652-3p0.1640.00214Xhsa-miR-1273 g-3p0.3820.005491hsa-miR-21-5p0.1650.0005917hsa-miR-4668-5p0.3860.000139hsa-miR-142-5p0.1750.0005617hsa-miR-20b-3p0.3900.01073Xhsa-miR-36530.1780.0011722hsa-miR-148a-3p0.3910.000757hsa-miR-27b-3p0.1880.001339hsa-miR-483-3p0.3921.4E-0511hsa-miR-299-3p0.1910.0011214hsa-miR-44500.3930.000684hsa-miR-1260a0.1937.5E-0514hsa-miR-93-5p0.4000.007367hsa-miR-4445-5p0.2028.2E-053hsa-miR-56840.4050.
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