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6 publications mentioning hsa-mir-1273c

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1273c. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 33
Other miRNAs from this paper: hsa-mir-1273h
Arrangement of the miR-1273 Family's Binding Sites in the mRNA of Target Genes. [score:3]
This analysis of the localization of paired miR-1273 binding sites in the mRNA of target genes leads to the conclusion that they evolved from a common ancestor. [score:3]
With a length of 22 nt, miR-1273c is coded in an intron of the T cell lymphoma invasion and metastasis 2 gene (TIAM2), located on chromosome 6. We found that 84 target gene mRNAs have one binding site for miR-1273c, while GOLGA3 has 2 sites, for a total of 86 miR-1273c sites. [score:3]
The adaptation of miRNA binding sites to each member of the miR-1273 family or to their combinations could also be due to the evolution of target gene mRNA and their varying functions. [score:3]
Such compactness in the binding site location of the miR-1273 family could be a result of embedding one general nucleotide sequence into the target genes. [score:3]
Some members of the miR-1273 family have a greater number of target genes than others. [score:3]
The distances described above between the pair binding sites of the miR-1273 family are nearly always matched in the target gene mRNA. [score:3]
The complementary nucleotide sequence to pre-miR-1273h includes binding sites for the miR-1273 family, and it is the most probable precursor for these segments (Figure 12). [score:1]
Members of the miR-1273 family have different origins, lengths, quantities, and properties of the miRNA binding sites, among other features. [score:1]
The location of paired miR-1273g-3p and miR-1273c binding sites is identical in both the mRNA 5′UTRs and the 3′UTRs (Figure 8). [score:1]
This study revealed that several hundred mRNAs have homologous nucleotide sequences containing binding sites for members of the miR-1273 family. [score:1]
The mRNAs of four genes have paired miR-1273g-3p and miR-1273c binding sites located in their 5′UTRs; two nucleotides are common to two sites (Figure 8). [score:1]
A feature of the miR-1273 family that this study discovered is the presence of pair binding sites in mRNA segments of 100 nucleotides. [score:1]
Features of the miR-1273 Family. [score:1]
Both miR-1273g-3p and miR-1273c have two overlapped nucleotides and pair binding sites, whose schemes are shown in Figure 8. The nucleotide sequences of miR-1273g-3p and miR-1273h have 16 overlapped nucleotides (Figure 12) that correspond to overlapping of their binding sites, shown in Figure 11. [score:1]
Arrangement of the Binding Sites of the miR-1273 Family in mRNA. [score:1]
However, all of the pair binding sites of the miR-1273 family have deviations of one-two nucleotides between them. [score:1]
Specifically, we examined pairs composed of miR-1273g-3p with another member of the miR-1273 family. [score:1]
Highly conserved binding sites of miR-1273 family in a large number of genes testify about their emergence in the early stages in human evolution. [score:1]
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2
[+] score: 20
Expression of miR-567 and miR-1273c was not detectable in colonic mucosae and colorectal cell lines (C [T]>36 cycles) (data not shown); whereas miR-1303 appeared to be fairly expressed in both normal and tumor colonic cells (Figure 5B). [score:5]
Our analysis allowed the identification of 3 MSI -targeted miRNAs: hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303. [score:3]
Note that hsa-mir-644 is included in the group of miRNAs rarely or not mutated in MSI CRCs (n = 18, frequency of mutation <25%) whereas hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303 constitute the group of miRNAs frequently altered (n = 3, frequency of mutation >75%). [score:3]
Note that hsa-mir-644 is incorporated in the group of miRNAs frequently altered, that also includes hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303 (n = 4, frequency of mutation >45%). [score:2]
A bi-allelic mutation was also noted in 36%, 57% and 83% of altered MSI CRC cell lines for mir-1273c, mir-567 or mir-1303, respectively (Figure 4, Table S2). [score:2]
MNR instabilities in hsa-mir-1273c (T11), hsa-mir-567 (A13) and hsa-mir-1303 (T13). [score:1]
The second group contained 3 miRNA genes (hsa-mir-1273c, hsa-mir-567 and hsa-mir-1303) frequently mutated in MSI CRCs (≥75%). [score:1]
0031862.g004 Figure 4MNR instabilities in hsa-mir-1273c (T11), hsa-mir-567 (A13) and hsa-mir-1303 (T13). [score:1]
By screening the quasi totality of MNR and DNR (≥7 repeat units) contained in miRbase-V15-annotated miRNA hairpin sequences, hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567 were demonstrated to be mutated at high frequency in both CRC cell lines and primary tumors. [score:1]
Similar alterations were found in MSI primary tumors with the exception of hsa-mir-1273c, which generally displayed smaller levels of alterations in tumors (only 1 bp- deletion) (Figure 4, Table S2). [score:1]
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3
[+] score: 3
Besides, the newly detected 3p arms of hsa-mir-511-1, hsa-mir-511-2, hsa-mir-1273c and hsa-mir-1247 also have higher expression levels than the originally annotated 5p arm. [score:3]
[1 to 20 of 1 sentences]
4
[+] score: 3
A total of twelve miRNAs were found to be commonly regulated over time in these three tissues; let-7d, let-7e, miR-1249, miR-1254, miR-1255, miR-1273, miR-1285, miR-1301, miR-1306, miR-548, and miR-8078. [score:2]
Binding sites of the miR-1273 family, miR-1285-3p and miR-5684 in human mRNAs. [score:1]
[1 to 20 of 2 sentences]
5
[+] score: 1
As demonstrated in Supplementary Table S1, five miRNAs belong to the hsa-miR-1273 family, which does not have well-documented anti-/pro-cancer properties, while among detected four members of the hsa-miR-30 family, hsa-miR-30c is reportedly involved promoting the invasiveness of metastatic breast cancer cells 11. [score:1]
[1 to 20 of 1 sentences]
6
[+] score: 1
01720Xhsa-miR-652-3p0.1640.00214Xhsa-miR-1273 g-3p0.3820.005491hsa-miR-21-5p0.1650.0005917hsa-miR-4668-5p0.3860.000139hsa-miR-142-5p0.1750.0005617hsa-miR-20b-3p0.3900.01073Xhsa-miR-36530.1780.0011722hsa-miR-148a-3p0.3910.000757hsa-miR-27b-3p0.1880.001339hsa-miR-483-3p0.3921.4E-0511hsa-miR-299-3p0.1910.0011214hsa-miR-44500.3930.000684hsa-miR-1260a0.1937.5E-0514hsa-miR-93-5p0.4000.007367hsa-miR-4445-5p0.2028.2E-053hsa-miR-56840.4050. [score:1]
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