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2 publications mentioning gga-mir-3525

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-3525. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 36
Target genes of 14 differentially expressed miRNAs (gga-miR-122-5p, gga-miR-193a-5p, gga-miR-194, gga-miR-215-5p, gga-miR-217-3p, gga-miR-375, gga-miR-1559-3p, gga-miR-1769-3p, gga-miR-1788-3p, gga-miR-1798-5p, gga-miR-2954, gga-miR-3525, and gga-miR-3531-3p) were predicted by using the miRDB and TargetScan programs. [score:7]
The SP group significantly increased gga-miR-3525 expression on day 1 after the infection and gga-miR-193a-5p expression on day 3 after the infection (Figure 3), in comparison with the S group. [score:5]
In comparison with the S group, the SP group significantly increased gga-miR-3525 (1.783-fold change) expression on day 1 after the infection and gga-miR-193a-5p and gga-miR-122-5p expression on day 3 after the infection (1.719- and 1.860-fold changes, respectively). [score:5]
In particular, miR-3525 and miR-193a-5p were found to indirectly target IL-6 and IFN-γ. [score:4]
On the other hand, the SP group significantly reduced expression of gga-miR-3525 and gga-miR-122-5p on day 5 post the infection (15.227- and 5.509-fold changes, respectively). [score:3]
A total of 14 differentially expressed miRNAs were detected (gga-miR-2954, gga-miR-215-3p, gga-miR-1798-5p, gga-miR-194, gga-miR-217-3p, gga-miR-1769-3p, gga-miR-1788-3p, gga-miR-1559-3p, gga-miR-3531-3p, gga-miR-215-5p, gga-miR-3525, gga-miR-193a-5p, gga-miR-122-5p, and gga-miR-375). [score:3]
To confirm and quantify the differential expression, five miRNAs (gga-miR-215-5p, gga-miR-3525, gga-miR-193a-5p, gga-miR-122-5p, and gga-miR-375) were randomly selected and validated by RT-PCR with six replicates of cecal samples in each group (Figure 3). [score:3]
Gga-miR-3525 was a unique miRNA to chickens and has been reported in the lung and tracheae of avian influenza virus infection chickens (24) and targets interleukin 6 signal transducer (IL6ST). [score:3]
Three days post the challenge, expression of gga-miR-215-5p and gga-miR-3525 decreased significantly, while gga-miR-193a-5p increased in the S, SP, and P groups as compared with the NC group. [score:2]
miR-1769-3p, miR-3531-3p, miR-1559-3p, miR-1798-5p, miR-1788-3p, miR-2954, and miR-3525 have not been found in the human and mouse genomes. [score:1]
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[+] score: 1
For example, the predicted novel chicken miRNA gga-m0015-3p is complementary to the known chicken miRNA gga-miR-126-5p, the 3′ portion of gga-m0016-5p overlaps with the 5′ portion of gga-miR-219b, and the 5′ portion of gga-m0028-3p overlaps with the 3′ portion of gga-miR-3525 (Figure S2). [score:1]
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