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2 publications mentioning hco-lin-4

Open access articles that are associated with the species Haemonchus contortus and mention the gene name lin-4. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 6
Of the highly expressed miRNAs common to both parasites, five (lin-4, mir-45, mir-50, mir-71, mir-228) are shared with C. elegans, where all except mir-50 are also abundant (using the same read number criteria) [42]. [score:3]
Genetic analysis in the free-living nematode Caenorhabditis elegans led to the discovery of the first miRNA, lin-4, which controls hypodermal cell fate decisions during early larval development [17, 18]. [score:2]
For both B. pahangi and H. contortus, lin-4 was found at higher abundance in L3 of both species compared to adult worms, a profile similar, but not identical, to the lin-4 expression profile in C. elegans. [score:1]
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[+] score: 4
In the L4 libraries, hco-miR-5885a-3p, hco-miR-5885b-3p, hco-miR-5885c-3p, hco-miR-5908-3p, hco-lin-4-5p, hco-miR-83-3p and sequences homologous to cel-let-7-5p and asu-miR-100a-5p, not previously identified from H. contortus, are all highly expressed in the L4 EV-enriched and have lower read counts in the L4 EV -depleted libraries. [score:3]
Interestingly a number of these (asu- miR-100a-5p, miR-60-3p, miR-71-5p, let-7-5p, lin-4-5p and miR-5885a, b, c-3p) were also present in EV libraries prepared from H. polygyrus adult stage [9], while miR-100a-5p and let-7-5p were recently identified in adult EV of the clade I nematode Trichuris muris [21]. [score:1]
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