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17 publications mentioning chi-mir-21

Open access articles that are associated with the species Capra hircus and mention the gene name mir-21. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 105
miR-328 was found downregulated in goats but upregulated in sheep; two miRNAs—miR-2285f-2 and miR-27a-5p were found upregulated in goats but downregulated in sheep; six miRNAs—miR-320a-1, miR-320a-2, miR-1246, miR-363, miR-760-3p, and miR-21-3p were upregulated and two miRNAs—miR-34b and miR-150 were downregulated in both species (Figure 1B and Table 3). [score:19]
In PPRV infected sheep lung, the upregulated miRNAs—miR-21-3p and miR-320a govern immune genes—TRAF6, EGFR, and ERBB4 and the downregulated miR-27a-5p potentially modulates the expression of genes—MAP3K7 and MAPK8IP3, involved in JNK signaling pathways (Figure 3B). [score:9]
miRNAs Role Tissue Reference miR-27a-5p Repression of viral replication Lung Roberts et al., 2011b miR-21-3p Induce apoptosis Lung Lo et al., 2013 miR-320a Inhibit virus infection Lung Sun et al., 2014 miR-1246 Promotes virus cytotoxicity Lung Sheng et al., 2014 miR-363 Induced apoptosis Lung and spleen Zhang et al., 2014 miR-760-3p Very highly upregulated Lung and spleen – FIGURE 2 Overview of the miRNA prediction and identification of miRNAs that regulated dysregulated proteins. [score:8]
miRNAs Role Tissue Reference miR-27a-5p Repression of viral replication Lung Roberts et al., 2011b miR-21-3p Induce apoptosis Lung Lo et al., 2013 miR-320a Inhibit virus infection Lung Sun et al., 2014 miR-1246 Promotes virus cytotoxicity Lung Sheng et al., 2014 miR-363 Induced apoptosis Lung and spleen Zhang et al., 2014 miR-760-3p Very highly upregulated Lung and spleen – FIGURE 2 Overview of the miRNA prediction and identification of miRNAs that regulated dysregulated proteins. [score:8]
Of these 20 common DEmiRNAs, miR-21-5p was the most upregulated (log [2]FC = 2.35) and miR-199b was the most downregulated DEmiRNA (log [2]FC = -3.03) in the spleen of goats. [score:7]
MicroRNA-21-3p, a berberine -induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth. [score:7]
Among these 31 DEmiRNAs, six DEmiRNAsmiR-21-3p, miR-320a, miR-27a-5p, miR-1246 (expressed in lung of both species), miR-760-3p and miR-363 (expressed in lung and spleen of both species) were selected based on their role in viral infection, apoptosis and fold change. [score:5]
These miRNAs include miR-21-3p, miR-320a, miR-27a-5p, and miR-1246—expressed in lung of both species; miR-760-3p and miR-363—expressed in lung and spleen of both species (Figure 2). [score:5]
However, in infected lung miR-21-3p was found upregulated on qPCR though not found in small RNA sequencing data in both the species (Figure 5 and Table 5). [score:4]
The upregulation of miR-21-3p and miR-363 in PPRV infections suggests synergistic effect of these miRs along with the virus in inducing apoptosis. [score:4]
This suggests that PPRV -induced miR-21-3p, miR-320a, and miR-363 might act cooperatively to enhance viral pathogenesis in the lung and spleen of sheep by downregulating several immune response genes. [score:4]
To further validate the expression of DEmiRNAs from high-throughput sequencing, qPCR was performed on three DEmiRNAsmiR-21-3p, miR-363, and miR-760-3p. [score:3]
Among these 11 common DEmiRNAs, the expression of miR-21-3p, miR-760-3p, and miR-27a-5p was more abundant in lungs of PPRV infected goats with log [2] fold change of 5.82, 3.79, and 3.07, respectively, while miR-34b (log [2]FC = -2.53) and miR-2285f-2 (log [2]FC = -2.53) were found least abundant in lungs of goats and sheep, respectively. [score:3]
Lung (goats)Lung (sheep)Spleen (goats)Spleen (sheep) miRNAsqPCR (log [2] fold changemiRNA-seq (log [2] fold change)qPCR (log [2] fold change)miRNA-seq (log [2] fold change)qPCR (log [2] fold change)miRNA-seq (log [2] fold change)qPCR (log [2] fold change)miRNA-seq (log [2] fold change) miR-21-3p +6.619 +5.826 +4.344 +1.753 +0.189 – +0.097 – miR-363 +5.823 +2.425 +0.345 +1.049 +0.618 +1.555 +0.474 +1.286 miR-760-3p +5.433 +3.798 +0.629 +1.242 +2.199 +1.637 +1.784 +1.679 PPR is a major threat to livestock keepers in developing countries, causing a severe disease in goats and sheep. [score:3]
The expression of miR-21-3p was found to be in concordance with the sequencing results in PPRV infected spleen of both the species. [score:3]
PPRV infection in spleen and lung triggered the expression of many immune-related miRNAs, including, miR-21, miR-150, miR-146b, and let-7 family as reported in Japanese encephalitis virus infection (Cai et al., 2015). [score:3]
TRAF6, a major element in IFN production (Yoshida et al., 2008) was suppressed by PPRV -induced miR-21-3p and miR-320a in the lung of sheep. [score:3]
In the miRNA–protein network of lung tissue of goats, three miRNAs—miR-21-3p, miR-363, and miR-320a mutually regulate EGFR (epidermal growth factor receptor), which is involved in immune response. [score:2]
The TRIM (tripartite motif family) family members TRIM24, TRIM36, and TRIM45 were identified to be modulated by miR-1246, miR-320a, and miR-21-3p, respectively. [score:1]
The change in the miRNA expression of miR-21-3p, miR-363, and miR-760-3p was calculated with U6snRNA as reference gene for normalization. [score:1]
Lung (goats)Lung (sheep)Spleen (goats)Spleen (sheep) miRNAsqPCR (log [2] fold changemiRNA-seq (log [2] fold change)qPCR (log [2] fold change)miRNA-seq (log [2] fold change)qPCR (log [2] fold change)miRNA-seq (log [2] fold change)qPCR (log [2] fold change)miRNA-seq (log [2] fold change) miR-21-3p +6.619 +5.826 +4.344 +1.753 +0.189 – +0.097 – miR-363 +5.823 +2.425 +0.345 +1.049 +0.618 +1.555 +0.474 +1.286 miR-760-3p +5.433 +3.798 +0.629 +1.242 +2.199 +1.637 +1.784 +1.679 Viral infection in the lung and spleen of sheep and goats infected with PPRV was confirmed by RT-PCR of 351 bp N gene amplicon in lung and spleen (Supplementary Figure S1). [score:1]
miR-21-3p induce apoptosis (Lo et al., 2013) and PPRV is also reported to cause apoptosis of host cells (Mondal et al., 2001). [score:1]
This study revealed that PPRV -induced miR-21-3p, miR-320a, and miR-363 might act cooperatively to enhance viral pathogenesis, which warrants further research. [score:1]
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[+] score: 31
There is a temporal relationship between the up-regulation of miR-21 and the posttranscriptional regulation of programmed cell death 4 (PDCD4) during porcine oocyte maturation [13]. [score:5]
The 10 most highly expressed miRNAs (miR-99a, miR-148a, miR-143, miR-10b, miR-26a, miR-21, miR-125b, miR-27b, let-7f, and miR-101) identified in the present study were also highly expressed in the ovaries of goats 18, 20, pigs [22], and other animal species as reviewed by Li et al. [9]. [score:5]
The 10 most abundant miRNAs (miR-99a-5p, miR-148a-3p, miR-143-3p, miR-10b-5p, miR-26a-5p, miR-21-5p, miR-125b-5p, miR-27b-3p, let-7f-5p, and miR-101-3p) were the same in the two libraries, of which miR-21-5p was defined as differentially expressed miRNA with a higher level in the prolific library than in the non-prolific library, but the remaining nine miRNAs did not meet the criteria of differentially expressed miRNA between the breeds (Table  3). [score:5]
The expression levels of six randomly selected miRNAs, including three known miRNAs (miR-21-5p, miR-127-3p and miR-199b-5p) and three novel miRNAs (miR-93, miR-20 and miR-81), were verified in the ovaries of prolific JTGs (n = 5) and non-prolific TBGs (n = 5) using RT-qPCR. [score:3]
Various miRNAs were expressed in GCs (miR-143, miR-125b, let-7 family, miR-21, miR-10b, miR-378, etc. ) [score:3]
The top 10 most significantly differentially expressed miRNAs were miR-21, miR-199b, miR-199c, miR-127, miR-200a, miR-379, miR-200b, miR-204, miR-411a, and miR-493. [score:3]
The top 10 most significantly differentially expressed miRNAs (miR-21, miR-199b, miR-199c, miR-127, miR-200a, miR-379, miR-200b, miR-204, miR-411a, miR-493) were analysed. [score:3]
miR-21, miR-99a, miRNA-143, let-7f, miR-493 and miR-200b may play important roles in follicular development. [score:2]
miR-21 plays an important role in the posttranscriptional regulation of transcripts involved in the prevention of apoptosis of murine GCs. [score:2]
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[+] score: 23
In the study, the expression of miR-21 in the Luts was significantly higher than which in the Fols, while, the expression of miR-125a in the Fols was significantly higher than which in the Luts. [score:5]
Let-7f, miR-125a and miR-21 were the top three differentially expressed known miRNAs between the two libraries. [score:3]
The expression of miR-21, miR-125b, let-7a and let-7b accounted for 40 % of all sequences (McBride et al. 2012). [score:3]
miR-21 could inhibit apoptosis of factor promoting survival of follicles and follicular transition to luteal (Easow et al. 2007; Kanehisa et al. 2008). [score:3]
The top three highest differentially expressed miRNA in two libraries was let-7f, miR-21 and miR-125a. [score:3]
The highest expressed known miRNA was let-7f in the two libraries, followed by the miR-21, miR-125a in the follicular and the luteal phase libraries, respectively. [score:3]
miR-21 can promote the survival of follicular cells during ovulation (Newcomb et al. 2015). [score:1]
It was inferred that miR-21, let-7f, miR-125a may be related to Fols-Luts transition in Anhuai goats. [score:1]
Let-7b and miR-125a can promote angiogenesis in the corpus luteum, and miR-21 can promote the survival of follicular cells during ovulation (Newcomb et al. 2015). [score:1]
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[+] score: 15
Increased expression of miR-21 was shown to promote pseudorabies virus (PRV) replication by targeting IP-10 (Huang et al., 2014). [score:5]
Pseudorabies viral replication is inhibited by a novel target of miR-21. [score:5]
In our study, miR-23, miR-26a, and miR-21 were downregulated following CPIV3 infection, respectively. [score:4]
In addition, IFN-gamma inducible protein (IP-10) was negatively correlated with miR-21. [score:1]
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[+] score: 14
Increased LH secretion after becoming pregnant, followed by upregulation of miR-21 expression, may contribute to the transformation of ovarian granulosa cells into luteal cells. [score:6]
In the previous studies, miR-21 exerted an anti-apoptotic effect during the transformation of ovarian granulosa cells into luteal cells, and repression of miR-21 expression induced granulosa cell apoptosis and significantly reduced the rate of ovulation, via a mechanism dependent on luteinizing hormone secretion [35]. [score:3]
Interestingly, the present study also showed that miR-21 was significantly upregulated in pregnant goat ovaries, compared to non-pregnant goat ovaries (1.92-fold). [score:3]
Also, miR-21 was demonstrated to express at significantly higher levels in the ovaries of Holstein cows compared to the testis (1.97-fold), indicating that miR-21 may play an important role in ovarian function [29]. [score:2]
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[+] score: 13
MiRNA-29b promotes high-fat diet-stimulated endothelial permeability and apoptosis in apoE knock-out mice by down -regulating MT1 expression [84], miR-21 is overexpressed in response to high glucose and protects endothelial cells from apoptosis by targeting death-domain associated protein [85]. [score:9]
In addition, miR-21 is highly expressed in the sub-luminal ESC cells at implantation sites is regulated in active blastocysts in the mouse [68]. [score:4]
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[+] score: 9
Additionally, miR-21, −101, −103 and −143 are more abundantly expressed in the bovine mammary gland [34], which suggests that these miRNAs may play an important role in the development or physiology of this tissue. [score:4]
For example, miR-21 is a small multi-faceted RNA that plays an extensive regulatory role in female physiology [35], the uterus [55], adipose tissue [56], skeletal myoblasts [57], immune reactions [35] and almost all forms of cancer [58]. [score:2]
Interestingly, the 13 of the top 20 most abundant miRNAs (let-7a, -7b, 7c, 7f, 7g, miR-21, −30a, −103, −107, −143, −148a, −320 and −423-5p) in the mammary gland also appear in the top 20 most abundant miRNAs in raw milk, which shows that these miRNAs in milk originate from the cells of the mammary gland. [score:1]
We found that 6 miRNAs, including miR-21, −30a, −101, −103/107 and −148a, were among the top 20 most abundant miRNAs in the above-mentioned tissues or organs (Table S7). [score:1]
Moreover, seven of these miRNAs, let-7a, let-7b, let-7c, let-7f, miR-21, miR-29a and miR-143, were detected in both goat and sheep. [score:1]
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[+] score: 8
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-148a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-215, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-mir-15b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-143, hsa-mir-152, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-184, hsa-mir-200c, hsa-mir-155, hsa-mir-29c, hsa-mir-200a, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-342, hsa-mir-148b, hsa-mir-451a, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-15b, ssc-mir-184, ssc-mir-224, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-let-7f-1, ssc-mir-103-1, ssc-mir-21, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-671, hsa-mir-378d-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-16b, bta-mir-21, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-27b, bta-mir-31, bta-mir-15b, bta-mir-215, bta-mir-30e, bta-mir-148b, bta-mir-192, bta-mir-200a, bta-mir-200c, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-10b, bta-mir-24-2, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-mir-342, bta-let-7f-1, bta-let-7a-2, bta-let-7a-3, bta-mir-103-2, bta-mir-125b-2, bta-mir-15a, bta-mir-99b, hsa-mir-664a, ssc-mir-99b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, bta-mir-141, bta-mir-143, bta-mir-146a, bta-mir-152, bta-mir-155, bta-mir-16a, bta-mir-184, bta-mir-24-1, bta-mir-223, bta-mir-224, bta-mir-26a-1, bta-mir-296, bta-mir-29d, bta-mir-378-1, bta-mir-451, bta-mir-486, bta-mir-671, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, ssc-mir-181a-1, ssc-mir-215, ssc-mir-30a, bta-mir-2318, bta-mir-2339, bta-mir-2430, bta-mir-664a, bta-mir-378-2, ssc-let-7a-1, ssc-mir-378-1, ssc-mir-29a, ssc-mir-30e, ssc-mir-499, ssc-mir-143, ssc-mir-10b, ssc-mir-486-1, ssc-mir-152, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-99a, ssc-mir-148b, ssc-mir-664, ssc-mir-192, ssc-mir-342, ssc-mir-125b-1, oar-mir-21, oar-mir-29a, oar-mir-125b, oar-mir-181a-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-296, ssc-mir-155, ssc-mir-146a, bta-mir-148c, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-664b, hsa-mir-378j, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-31, ssc-mir-671, bta-mir-378b, bta-mir-378c, hsa-mir-486-2, oar-let-7a, oar-let-7f, oar-mir-103, oar-mir-10b, oar-mir-143, oar-mir-148a, oar-mir-152, oar-mir-16b, oar-mir-181a-2, oar-mir-200a, oar-mir-200b, oar-mir-200c, oar-mir-23a, oar-mir-26a, oar-mir-29b-1, oar-mir-30a, oar-mir-99a, bta-mir-664b, chi-let-7a, chi-let-7f, chi-mir-103, chi-mir-10b, chi-mir-125b, chi-mir-126, chi-mir-141, chi-mir-143, chi-mir-146a, chi-mir-148a, chi-mir-148b, chi-mir-155, chi-mir-15a, chi-mir-15b, chi-mir-16a, chi-mir-16b, chi-mir-184, chi-mir-192, chi-mir-200a, chi-mir-200b, chi-mir-200c, chi-mir-215, chi-mir-223, chi-mir-224, chi-mir-2318, chi-mir-23a, chi-mir-24, chi-mir-26a, chi-mir-27b, chi-mir-296, chi-mir-29a, chi-mir-29b, chi-mir-29c, chi-mir-30a, chi-mir-30e, chi-mir-342, chi-mir-378, chi-mir-451, chi-mir-499, chi-mir-671, chi-mir-99a, chi-mir-99b, bta-mir-378d, ssc-mir-378b, oar-mir-29b-2, ssc-mir-141, ssc-mir-200b, ssc-mir-223, bta-mir-148d
Ye et al. (2012) examined miRNA expression in the duodenum of E. coli F18-sensitive and -resistant weaned piglets and identified 12 candidate miRNA (ssc-miR-143, ssc-let-7f, ssc-miR-30e, ssc-miR-148a, ssc-miR-148b, ssc-miR-181a, ssc-miR-192, ssc-miR-27b, ssc-miR-15b, ssc-miR-21, ssc-miR-215, and ssc-miR-152) disease markers. [score:5]
Additionally, a number of miRNAs including miR-148a, miR-26a, miR-21-5p, miR-27b, miR-143, bta-miR-30a-5p, let-7a-5p, let-7f, miR-10b, and miR-99a-5p are highly expressed in bovine mammary gland/mammary epithelial cells (Li et al., 2012a, 2014a; Jin et al., 2014a; Le Guillou et al., 2014) suggesting roles in the lactation process and mammary gland functions. [score:3]
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[+] score: 7
Of the 29, miR-10b, miR-125b, and miR-145 were down-regulated, while miR-21 and miR-155 were up-regulated [6]. [score:7]
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[+] score: 7
MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer. [score:4]
Interestingly, let-7i-5p, let-7f-5p, and miR-21-5p are highly expressed in the porcine ovary and testis, suggesting that they are associated with secretory function (Li et al., 2011). [score:3]
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[+] score: 7
In the mammary glands of lactating goats, we found that miRNAs associated with cell proliferation (miR-26a, miR-21), conferring epithelial phenotype (miR-29a, miR-30a/d), immune response and development (miR-181, let-7a/b/f/g/i) were abundantly expressed, as well as miRNAs involved in lipid metabolism (miR-103, miR-23a, miR-27b, miR-200a/b/c). [score:4]
Specifically, miR-26a (cell proliferation) was the most abundantly expressed, followed by miR-148 (may control insulin content) and miR-21 (cell proliferation). [score:3]
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[+] score: 4
However, the expression of miR-21 also have no significant difference between multiple and uniparous groups in this study. [score:3]
MiR-21 was verified in regulation of apoptosis in vivo, and related with ovulation rate [46]. [score:1]
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[+] score: 3
In the present study high levels of expression of miR-10b, miR-125b, miR-143, miR145, miR199b, miR21 and miR-99a were recorded in the ovary. [score:3]
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[+] score: 3
Other miRNAs from this paper: mmu-mir-1a-1, mmu-mir-127, mmu-mir-134, mmu-mir-136, mmu-mir-154, mmu-mir-181a-2, mmu-mir-143, mmu-mir-196a-1, mmu-mir-196a-2, mmu-mir-21a, rno-mir-329, mmu-mir-329, mmu-mir-1a-2, mmu-mir-181a-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-375, mmu-mir-379, mmu-mir-181b-2, rno-mir-21, rno-mir-127, rno-mir-134, rno-mir-136, rno-mir-143, rno-mir-154, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-196a, rno-mir-181a-1, mmu-mir-196b, rno-mir-196b-1, mmu-mir-412, mmu-mir-370, oar-mir-431, oar-mir-127, oar-mir-432, oar-mir-136, mmu-mir-431, mmu-mir-433, rno-mir-431, rno-mir-433, ssc-mir-181b-2, ssc-mir-181c, ssc-mir-136, ssc-mir-196a-2, ssc-mir-21, rno-mir-370, rno-mir-412, rno-mir-1, mmu-mir-485, mmu-mir-541, rno-mir-541, rno-mir-493, rno-mir-379, rno-mir-485, mmu-mir-668, bta-mir-21, bta-mir-181a-2, bta-mir-127, bta-mir-181b-2, bta-mir-181c, mmu-mir-181d, mmu-mir-493, rno-mir-181d, rno-mir-196c, rno-mir-375, mmu-mir-1b, bta-mir-1-2, bta-mir-1-1, bta-mir-134, bta-mir-136, bta-mir-143, bta-mir-154a, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-329a, bta-mir-329b, bta-mir-370, bta-mir-375, bta-mir-379, bta-mir-412, bta-mir-431, bta-mir-432, bta-mir-433, bta-mir-485, bta-mir-493, bta-mir-541, bta-mir-181a-1, bta-mir-181b-1, ssc-mir-1, ssc-mir-181a-1, mmu-mir-432, rno-mir-668, ssc-mir-143, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-196b-1, ssc-mir-127, ssc-mir-432, oar-mir-21, oar-mir-181a-1, oar-mir-493, oar-mir-433, oar-mir-370, oar-mir-379, oar-mir-329b, oar-mir-329a, oar-mir-134, oar-mir-668, oar-mir-485, oar-mir-154a, oar-mir-154b, oar-mir-541, oar-mir-412, mmu-mir-21b, mmu-mir-21c, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-370, ssc-mir-493, bta-mir-154c, bta-mir-154b, oar-mir-143, oar-mir-181a-2, chi-mir-1, chi-mir-127, chi-mir-134, chi-mir-136, chi-mir-143, chi-mir-154a, chi-mir-154b, chi-mir-181b, chi-mir-181c, chi-mir-181d, chi-mir-196a, chi-mir-196b, chi-mir-329a, chi-mir-329b, chi-mir-379, chi-mir-412, chi-mir-432, chi-mir-433, chi-mir-485, chi-mir-493, rno-mir-196b-2, bta-mir-668, ssc-mir-375
Using gene sequence comparisons and expression analysis, Lee and Ambros [23] reported that about 12% of miRNA in C. elegans, Drosophila and some plants are conserved and of these, miR-21, miR-234, miR-260 and miR-287 are highly conserved [23]. [score:3]
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[+] score: 2
Previous studies have identified a few miRNAs and revealed their function in HF morphogenesis and development, such as miR-214, miR-21, miR-24 and miR-196a [22– 24]. [score:2]
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[+] score: 2
However, in late lactation, miR-143, let-7, miR-21, miR-148, miR-30, miR-146, miR-107 and miR-103 were the most abundant, each with more than 100,000 reads. [score:1]
In two libraries, let-7, miR-143, miR-148, miR-378, miR-146 and miR-21 were detected with high abundance (Table S1). [score:1]
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[+] score: 1
In previous studies, several miRNAs (e. g., miR-200a and miR-21) were found to be involved in the cellular differentiation of mammary glands [7, 8]. [score:1]
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