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5 publications mentioning chi-mir-424

Open access articles that are associated with the species Capra hircus and mention the gene name mir-424. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 41
In the integrated analysis, the related miRNAs or DE-targets in each network were differentially-expressed miRNAs or genes, most of the miRNAs and DE-targets were involved in multiple pathways, for instance, miR-424-5p, miR-29a, bta-miR-129-3p, miR-181b and miR-181d. [score:7]
When it came to focal adhesion (Figure 6), 163 miRNAs and 17 genes were involved in, and miR-424-5p regulated 14 DE-targets, which was the largest number of DE targets. [score:6]
miR-424-5p was involved in most of the pathways, and significantly differentially expressed during different development stages, suggesting its important regulatory effect. [score:5]
miR-424-5p was involved in most of the 10 pathways, and regulated the largest number of DE-targets. [score:4]
It was very interesting that among the 7 networks, miR-424-5p were very active in that it regulates largest numbers of DE-targets and at the center of the networks. [score:4]
In this pathway, miR-424-5p regulated most numbers (16) of DE targets, which suggested its important role in this pathway. [score:4]
Moreover, except miR-424-5p and miR-29a, there were many other miRNAs that have important regulate effect in the network, further studies on these miRNAs would enable us to determine the mechanism of miRNAs in muscle development and miRNA-mRNA interaction. [score:3]
Based on the networks, we found that miRNA-424-5p and miR-29a had important regulatory effect during muscle development. [score:3]
This indicated that miR-424-5p might play an important role in regulation muscle development. [score:3]
Except miR-424-5p and miRNA-29a, miR-129-3p, miR-181b and miR-181d were also involved in multiple pathways. [score:1]
However, the biological characteristics, molecular mechanisms, and targets of miR-424-5p were not well-understood. [score:1]
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[+] score: 9
For example, miR-378-3p could increase the expression of MyoD by repressing MyoR in myoblast cells [39]; miR-424 promoted C2C12 myoblast differentiation via direct targeting of the 3´UTR of Cdc25A [40]. [score:6]
Some of these miRNAs showed very high expression levels with larger than 10,000 RPM (chi-miR-424-5p and chi-miR-542-3p). [score:3]
[1 to 20 of 2 sentences]
[+] score: 5
Through the generation of a knockout mouse mo del, Liobet-Navas and colleagues [24] demonstrated that the miR-424(322)/503 cluster orchestrates the remo delling of the epithelium in the involuting mammary gland, and these authors also showed the regression of secretory acini when the mammary gland is compromised in the absence of miR-424(322)/503, as these molecules orchestrate cell life and death decisions by targeting B-cell lymphoma-2 (BCL-2) and insulin-like growth factor 1 receptor (IGF1R). [score:4]
Liobet-Navas D The miR-424(322)503 cluster orchestrates remo deling of the epithelium in the involuting mammary glandGenes Dev. [score:1]
[1 to 20 of 2 sentences]
[+] score: 5
Examination of genome-wide miRNA expression in goats suggested that miR-424-5p and miR-29a regulate muscle development [14] and that miRNAs play an important role in endometrial receptivity [15]. [score:5]
[1 to 20 of 1 sentences]
[+] score: 3
Furthermore, in the P and D libraries, except for miR-151*, miR-126* and miR-455*, the expression levels of miRNA*s (miR-424*, −99a*, −142*, −7a*, −2411* and −21*) were much lower than those of their corresponding miRNAs (Table S5). [score:3]
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