Stem-loop cel-lin-4

Accession

MI0000002

Description

Caenorhabditis elegans cel-lin-4 precursor miRNA lin-4

Gene
family

RF00052; lin-4

Literature search

49 open access papers mention cel-lin-4
(381 sentences)

Sequence

348252 reads, 2214 reads per million, 15 experiments

augcuuccggccuguUCCCUGAGACCUCAAGUGUGAguguacuauugaugcuucACACCUGGGCUCUCCGGGUACCaggacgguuugagcagau
.((((((((.((((..(((.((((.((((.(((((((.((((....).)))))))))).)))).)))).)))...)))).)))...)))))...

Structure

--a     ---   g    -uU   U    C    A       u   - u 
   ugcuu   ccg ccug   CCC GAGA CUCA GUGUGAg gua c a
   |||||   ||| ||||   ||| |||| |||| ||||||| ||| |  
   acgag   ggc ggaC   GGG CUCU GGGU CACAcuu cgu g u
uag     uuu   a    CAU   C    C    C       -   a u 

Annotation confidence High

Comments

lin-4 is found on chromosome II in Caenorhabditis elegans [1] and is complementary to sequences in the 3' untranslated region (UTR) of lin-14 mRNA. lin-4 acts to developmentally repress the accumulation of lin-14 protein. This repression is essential for the proper timing of numerous events of Caenorhabditis elegans larval development [2].

Genome context

chrII: 5902254-5902347 [+]

Mature cel-lin-4-5p

• Accession: MIMAT0000002
• Description: Caenorhabditis elegans cel-lin-4-5p mature miRNA
• Sequence: 16 - UCCCUGAGACCUCAAGUGUGA - 36
• Evidence: experimental ; cloned [1,3-4], 454 [5], Illumina [6], CLIPseq [7]

Mature cel-lin-4-3p

• Accession: MIMAT0015092
• Description: Caenorhabditis elegans cel-lin-4-3p mature miRNA
• Sequence: 55 - ACACCUGGGCUCUCCGGGUACC - 76
• Evidence: experimental ; CLIPseq [7]

References

1. PubMed ID: 11679671
   An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
   "Lau NC, Lim LP, Weinstein EG, Bartel DP"
   "Science (2001) 294:858-862


2. PubMed ID: 12672692
   The microRNAs of Caenorhabditis elegans
   "Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP"
   "Genes Dev (2003) 17:991-1008


3. PubMed ID: 12747828
   MicroRNAs and other tiny endogenous RNAs in C. elegans
   "Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D"
   "Curr Biol (2003) 13:807-818


4. PubMed ID: 17174894
   Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
   "Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H, Bartel DP"
   "Cell (2006) 127:1193-1207


5. PubMed ID: 19460142
   Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development
   Kato M, de Lencastre A, Pincus Z, Slack FJ
   Genome Biol (2009) 10:R54


6. PubMed ID: 20062054
   Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
   "Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli AE, Yeo GW"
   "Nat Struct Mol Biol (2010) 17:173-179


7. PubMed ID: 10642801
   The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
   "Olsen PH, Ambros V"
   "Dev Biol (1999) 216:671-680