Accession
MI0000063
Symbol
HGNC:
MIRLET7B
Description
Homo sapiens
hsa-let-7b precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7B is the host gene for the microRNA miR-let-7b, which is known to increase during oxygen exposure, leading to oxidative stress and cellular senescence in the choroid and retinal pigment epithelium via the p53–let-7b–IGF-1R pathway [PMC9022335]. The regulation of MIRLET7B is complex, with LYPLAL1-AS1 directly interacting with its promoter to negatively control its activity [PMC9022335]. Additionally, FOXO3 is implicated in regulating MIRLET7B expression [PMC5695745]. The binding of LYPLAL1-AS1 to the MIRLET7B promoter has been mapped using ChIRP-seq technology [PMC9022335]. During retinal pigment epithelium epithelial-mesenchymal transition (RPE-EMT), MIRLET7B expression is upregulated after 12 hours of dissociation [PMC8024778]. Furthermore, mutated transcription factor NKX2-5 has been shown to positively influence MIRLET7B expression [PMC6566633]. Research has also been conducted on targeting miRNAs like those from MIRLET7B using a novel conditional allele in mouse embryonic stem cells [PMC3814644]. Despite these insights, the precise role of miR-let-7b in cellular senescence remains an area for further investigation [PMC9022335].
Literature search
1157 open access papers mention hsa-let-7b
(6991 sentences)
(6991 sentences)
Sequence
11516291
reads,
21812
reads per million, 159 experiments
cggggUGAGGUAGUAGGUUGUGUGGUUucagggcagugauguugccccucggaagauaaCUAUACAACCUACUGCCUUCCCug
(((((.(((((((((((((((((((((((.((((((.....))))))...))).....)))))))))))))))))))))))))
(((((.(((((((((((((((((((((((.((((((.....))))))...))).....)))))))))))))))))))))))))
Structure
U ----- --a u
cgggg GAGGUAGUAGGUUGUGUGGU Uuc gggcag g
||||| |||||||||||||||||||| ||| |||||| a
guCCC UUCCGUCAUCCAACAUAUCa agg cccguu u
- auaga cuc g
Annotation confidence
Medium
Do you think this miRNA is real?
Genome context
chr22: 46113686-46113768 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-let-7b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-let-7b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-let-7b-5p
| Accession | MIMAT0000063 |
| Description | Homo sapiens hsa-let-7b-5p mature miRNA |
| Sequence | 6 - UGAGGUAGUAGGUUGUGUGGUU - 27 |
| Evidence |
experimental
cloned [1,3-5], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-let-7b-3p
| Accession | MIMAT0004482 |
| Description | Homo sapiens hsa-let-7b-3p mature miRNA |
| Sequence | 60 - CUAUACAACCUACUGCCUUCCC - 81 |
| Evidence |
experimental
cloned [4-5] |
| Database links |
|
| Predicted targets |
|
References
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