Accession
MI0000063
Symbol
HGNC:
MIRLET7B
Description
Homo sapiens
hsa-let-7b precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7B is the host gene of miR-let-7b-5p (hereafter referred to as miR-let-7b) that is augmented during oxygen exposure, causing oxidative stress and senescence in the choroid and retinal pigment epithelium through the p53–let-7b–IGF-1R axis, but the role of miR-let-7b in cell senescence remains unclear [1]. LYPLAL1-AS1 directly interacts with the MIRLET7B promoter and regulates its activity negatively [1]. FOXO3 very likely regulates the expression of MIRLET7B and MIRLET7C [2]. LYPLAL1-AS1 binds to a specific region of the MIRLET7B promoter on chromosome 22, as shown by ChIRP-seq analysis using Integrative Genomics Viewer software [1]. During dissociation-induced retinal pigment epithelial epithelial-mesenchymal transition, several microRNA host genes, including MIRLET7B, are upregulated or downregulated at different time points [3]. The transcription factor NKX2-5 positively regulates target genes MIR29C and MIRLET7B when mutated [4]. A novel conditional allele for the bicistronic mirLet7c2 and MIRLET7B miRNAs was generated using homologous recombination in mouse ES cells for targeted manipulation of these specific microRNAs [5]. References: [1] PMC9022335 [2] PMC5695745 [3] PMC8024778 [4] PMC6566633 [5] PMC3814644
Literature search
1157 open access papers mention hsa-let-7b
(6991 sentences)
(6991 sentences)
Sequence
11518188
reads,
27396
reads per million, 159 experiments
cggggUGAGGUAGUAGGUUGUGUGGUUucagggcagugauguugccccucggaagauaaCUAUACAACCUACUGCCUUCCCug
(((((.(((((((((((((((((((((((.((((((.....))))))...))).....)))))))))))))))))))))))))
(((((.(((((((((((((((((((((((.((((((.....))))))...))).....)))))))))))))))))))))))))
Structure
U ----- --a u
cgggg GAGGUAGUAGGUUGUGUGGU Uuc gggcag g
||||| |||||||||||||||||||| ||| |||||| a
guCCC UUCCGUCAUCCAACAUAUCa agg cccguu u
- auaga cuc g
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr22: 46113686-46113768 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-let-7b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-let-7b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-let-7b-5p
| Accession | MIMAT0000063 |
| Description | Homo sapiens hsa-let-7b-5p mature miRNA |
| Sequence | 6 - UGAGGUAGUAGGUUGUGUGGUU - 27 |
| Evidence |
experimental
cloned [1,3-5], Northern [1] |
| Database links |
|
| Predicted targets |
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Mature hsa-let-7b-3p
| Accession | MIMAT0004482 |
| Description | Homo sapiens hsa-let-7b-3p mature miRNA |
| Sequence | 60 - CUAUACAACCUACUGCCUUCCC - 81 |
| Evidence |
experimental
cloned [4-5] |
| Database links |
|
| Predicted targets |
|
References
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