Accession
MI0000069
Symbol
HGNC:
MIR15A
Description
Homo sapiens
hsa-mir-15a precursor miRNA mir-15
Gene
family?
family?
RF00455;
mir-15
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-15a is a member of the hsa-mir-15 family cluster and has been identified as a tumor suppressor. It regulates the expression of oncogenes BCL2, CCND1, and WNT3, thereby inhibiting tumor growth [PMC5814839]. Hsa-mir-15a targets a total of 56 genes, including CCND1 [PMC5814839]. Hsa-miR-16, another member of the hsa-mir-15 family cluster, targets 63 genes including CCND1 [PMC5355656]. Hsa-miR-155 targets 20 genes, including CCND1 and SMAD2 [PMC5355656]. Hsa-miR-375 targets 44 genes, including AKT2 and CDK6 [PMC5355656]. Lastly, hsa-miR-429 targets 59 genes, including CCND1 [PMC5355656]. Among these microRNAs in the regulatory network studied, hsa-miR-16 targets the highest number of genes [PMC5355656]. In conclusion, hsa-mir-15a is a tumor suppressor that regulates oncogenes BCL2, CCND1 and WNT3. It is part of the hsa-mir-15 family cluster and has been shown to target 56 genes. Other microRNAs in this cluster such as hsa-miR16 also target CCND1 but target different numbers of total genes in the regulatory network studied. These findings highlight the importance of microRNAs in cancer regulation and provide potential therapeutic targets for cancer treatment.
Literature search
482 open access papers mention hsa-mir-15a
(1792 sentences)
(1792 sentences)
Sequence
565656
reads,
3371
reads per million, 143 experiments
ccuuggaguaaagUAGCAGCACAUAAUGGUUUGUGgauuuugaaaaggugCAGGCCAUAUUGUGCUGCCUCAaaaauacaagg
(((((.......(..((((((((..((((((((((.............))))))))))..))))))))..).......)))))
(((((.......(..((((((((..((((((((((.............))))))))))..))))))))..).......)))))
Structure
gaguaaa UA UA gauuu
ccuug g GCAGCACA AUGGUUUGUG u
||||| | |||||||| |||||||||| g
ggaac C CGUCGUGU UACCGGACgu a
auaaaaA UC UA ggaaa
Annotation confidence
High
Do you think this miRNA is real?
Comments
Reference [1] named this sequence miR-15. This is renamed miR-15a here to avoid confusion with miR-15b (MIR:MI0000438) identified later by others. This gene and miR-16 are clustered within 0.5 kb at 13q14. This region has been shown to be deleted in more than half of B cell chronic lymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted or down-regulated in more than two thirds of CLL cases [2].
Genome context
chr13: 50049119-50049201 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-15a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-15a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-15a-5p
| Accession | MIMAT0000068 |
| Description | Homo sapiens hsa-miR-15a-5p mature miRNA |
| Sequence | 14 - UAGCAGCACAUAAUGGUUUGUG - 35 |
| Evidence |
experimental
cloned [1,3-6], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-15a-3p
| Accession | MIMAT0004488 |
| Description | Homo sapiens hsa-miR-15a-3p mature miRNA |
| Sequence | 51 - CAGGCCAUAUUGUGCUGCCUCA - 72 |
| Evidence |
experimental
cloned [5] |
| Database links |
|
| Predicted targets |
|
References
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