miRBase entry: hsa-mir-25

Stem-loop hsa-mir-25

Homo sapiens hsa-mir-25 precursor miRNA
Gene family
MIPF0000013; mir-25

Caution, this is an AI generated summary based on literature. This may have errors. ?

Hsa-mir-25 has been found to have more targets in TargetScan compared to most other miRNAs, but fewer targets in miRanda [PMC5581471]. It is also one of the predicted miRNAs for ERS signature genes EDEM1 and BAX [PMC9022475]. In a miRNA expression profiling study, hsa-mir-25 was found to be upregulated in COLO 320 and COLO 205 cells, which are involved in the regulation of cell cycle, cell differentiation, migration, and invasion [PMC9941246]. Additionally, hsa-mir-25 has been implicated in the invasion of prostate cancer and may be involved in signaling mechanisms related to aurora kinase A or integrin [PMC8426106].

Literature search
252 open access papers mention hsa-mir-25
(933 sentences)


1044210 reads, 3994 reads per million, 148 experiments

    a      ag    G     UU G     UG    acg 
ggcc guguug  AGGC GAGAC  G GCAAU  cugg   c
|||| ||||||  |||| |||||  | |||||  ||||    
ccgg cgugac  UCUG CUCUG  C CGUUA  gguc   u
    c      AG    G     UU A     Cg    ccg 

Annotation confidence High
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Genome context
chr7: 100093560-100093643 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-25
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-25 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-25 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-25 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-25-5p

Accession MIMAT0004498
Description Homo sapiens hsa-miR-25-5p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets

Mature hsa-miR-25-3p

Accession MIMAT0000081
Description Homo sapiens hsa-miR-25-3p mature miRNA
Evidence experimental
cloned [1-4], Northern [1]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043