Accession
MI0000084
Symbol
HGNC:
MIR26B
Description
Homo sapiens
hsa-mir-26b precursor miRNA mir-26
Gene
family?
family?
RF00244;
mir-26
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR26B is a microRNA that has been found to play a role in the regulation of EZH2 expression [PMC6925750]. It has been suggested that the increase in EZH2 expression is due to the repression of microRNAs, including miR26a and MIR26B [PMC6925750]. Additionally, a specific region of gDNA, which includes MIR26B, has been identified and characterized. This region is 160 bp in length and is flanked by loxP sites, making it "floxed" [PMC8243710]. The identification of this specific region provides valuable information for further research on the role of MIR26B in gene regulation [PMC8243710]. The findings suggest that MIR26B may be an important factor in the regulation of EZH2 expression and could potentially be targeted for therapeutic interventions [PMC6925750]. Further studies are needed to fully understand the mechanisms by which MIR26B regulates gene expression and its potential implications in disease development and treatment [PMC6925750].
Literature search
259 open access papers mention hsa-mir-26b
(1137 sentences)
(1137 sentences)
Sequence
906667
reads,
3586
reads per million, 152 experiments
ccgggacccagUUCAAGUAAUUCAGGAUAGGUugugugcuguccagCCUGUUCUCCAUUACUUGGCUcggggaccgg
((((..((((((.((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..))))
((((..((((((.((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..))))
Structure
ga - U UC u ug
ccgg ccc agU CAAGUAAU AGGAUAGGUug g c
|||| ||| ||| |||||||| ||||||||||| |
ggcc ggg UCG GUUCAUUA UCUUGUCCgac c u
ag c - CC - ug
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr2: 218402646-218402722 [+]
Disease association
hsa-mir-26b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-26b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-26b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-26b-5p
| Accession | MIMAT0000083 |
| Description | Homo sapiens hsa-miR-26b-5p mature miRNA |
| Sequence | 12 - UUCAAGUAAUUCAGGAUAGGU - 32 |
| Evidence |
experimental
cloned [1,3-5], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-26b-3p
| Accession | MIMAT0004500 |
| Description | Homo sapiens hsa-miR-26b-3p mature miRNA |
| Sequence | 47 - CCUGUUCUCCAUUACUUGGCU - 67 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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