miRBase entry: hsa-mir-26b

Stem-loop hsa-mir-26b


Accession
MI0000084
Symbol
HGNC: MIR26B
Description
Homo sapiens hsa-mir-26b precursor miRNA mir-26
Gene
family?
RF00244; mir-26

Literature search
259 open access papers mention hsa-mir-26b
(1137 sentences)

Sequence

906667 reads, 3586 reads per million, 152 experiments
ccgggacccagUUCAAGUAAUUCAGGAUAGGUugugugcuguccagCCUGUUCUCCAUUACUUGGCUcggggaccgg
((((..((((((.((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..))))

Structure
    ga   -   U        UC           u ug 
ccgg  ccc agU CAAGUAAU  AGGAUAGGUug g  c
||||  ||| ||| ||||||||  ||||||||||| |   
ggcc  ggg UCG GUUCAUUA  UCUUGUCCgac c  u
    ag   c   -        CC           - ug 


Annotation confidence High
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Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr2: 218402646-218402722 [+]

Disease association
hsa-mir-26b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-26b is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-26b is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-26b-5p

Accession MIMAT0000083
Description Homo sapiens hsa-miR-26b-5p mature miRNA
Sequence 12 - UUCAAGUAAUUCAGGAUAGGU - 32
Evidence experimental
cloned [1,3-5], Northern [1]
Database links
Predicted targets

Mature hsa-miR-26b-3p

Accession MIMAT0004500
Description Homo sapiens hsa-miR-26b-3p mature miRNA
Sequence 47 - CCUGUUCUCCAUUACUUGGCU - 67
Evidence experimental
cloned [4]
Database links
Predicted targets

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043