miRBase entry: hsa-mir-26b

Stem-loop hsa-mir-26b

Homo sapiens hsa-mir-26b precursor miRNA
Gene family
MIPF0000043; mir-26

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR26B is a microRNA that has been found to play a role in the regulation of EZH2 expression [PMC6925750]. It has been suggested that the increase in EZH2 expression is due to the repression of microRNAs, including miR26a and MIR26B [PMC6925750]. Additionally, a specific region of gDNA, which includes MIR26B, has been identified and characterized. This region is 160 bp in length and is flanked by loxP sites, making it "floxed" [PMC8243710]. The identification of this specific region provides valuable information for further research on the role of MIR26B in gene regulation [PMC8243710]. The findings suggest that MIR26B may be an important factor in the regulation of EZH2 expression and could potentially be targeted for therapeutic interventions [PMC6925750]. Further studies are needed to fully understand the mechanisms by which MIR26B regulates gene expression and its potential implications in disease development and treatment [PMC6925750].

Literature search
259 open access papers mention hsa-mir-26b
(1137 sentences)


906667 reads, 3586 reads per million, 152 experiments

    ga   -   U        UC           u ug 
ccgg  ccc agU CAAGUAAU  AGGAUAGGUug g  c
||||  ||| ||| ||||||||  ||||||||||| |   
ggcc  ggg UCG GUUCAUUA  UCUUGUCCgac c  u
    ag   c   -        CC           - ug 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr2: 218402646-218402722 [+]

Disease association
hsa-mir-26b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-26b is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-26b is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-26b-5p

Accession MIMAT0000083
Description Homo sapiens hsa-miR-26b-5p mature miRNA
Evidence experimental
cloned [1,3-5], Northern [1]
Database links
Predicted targets

Mature hsa-miR-26b-3p

Accession MIMAT0004500
Description Homo sapiens hsa-miR-26b-3p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043