miRBase entry: hsa-mir-27a

Stem-loop hsa-mir-27a

Homo sapiens hsa-mir-27a precursor miRNA
Gene family
MIPF0000036; mir-27

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR27A is a microRNA that has been implicated in various biological processes and diseases. Transplantation of lipotoxic HC-exosomal MIR27A has been shown to impair mitochondrial functions and worsen fibrosis in MAFLD [PMC8607138]. In a cellular context, MIR27A, along with other candidate miRs such as miR144, miR153, and miR142-5p, can bind to Nrf2 through multiple distinct binding sites, potentially enhancing the targeting of Nrf2 and its associated functions [PMC3517581]. The influence of variants in MIR27A on the risk of coronary artery disease (CAD) has been evaluated, with rs895819, rs11614913, and rs2168518 variants being investigated [PMC9141586]. MIR27A may also play a role in stem cell and adipocyte differentiation [PMC6158720]. Rosiglitazone treatment was found to decrease the migration of 3T3-L1 preadipocytes compared to MIR27A transfected cells [PMC6158720]. The expression of VEGF and VEGFR1 was evaluated along with key transcription factors (Sp1, Sp3) and microRNAs (miR20a and MIR27A) in response to TA treatment [PMC7168141]. Chloroquine did not affect the processing of miR21 or MIR27A in control cells after pre-treatment [PMC3749859]. In Treg cells with reduced Dicer levels but overexpressed miRNAs such as let-7a, let-7f, miR-16, miR-23a/b, MIR27A, and miR-155 were observed [PMC3072673].

Literature search
380 open access papers mention hsa-mir-27a
(2322 sentences)


556854 reads, 3484 reads per million, 150 experiments

   a  a  A             U       g  u cac 
cug gg gc GGGCUUAGCUGCU GUGAGCA gg c   a
||| || || ||||||||||||| ||||||| || |    
gac cc CG CUUGAAUCGGUGA CACUUgu cu g   c
   c  c  C             -       g  - aac 

Annotation confidence High
Do you think this miRNA is real?
This miRNA was previously named miR-27 [1,2] but is renamed here to avoid confusion with the more recently described miR-27b (MIR:MI0000440).

Genome context
chr19: 13836440-13836517 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-27a
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-27a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-27a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-27a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-27a-5p

Accession MIMAT0004501
Description Homo sapiens hsa-miR-27a-5p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets

Mature hsa-miR-27a-3p

Accession MIMAT0000084
Description Homo sapiens hsa-miR-27a-3p mature miRNA
Evidence experimental
cloned [1,3-5], Northern [1]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728