Accession
MI0000085
Symbol
HGNC:
MIR27A
Description
Homo sapiens
hsa-mir-27a precursor miRNA mir-27
Gene
family?
family?
RF00644;
mir-27
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR27A, a microRNA, has been implicated in various biological processes and diseases. It has been shown to damage mitochondrial functions and exacerbate MAFLD-related fibrosis when transplanted via lipotoxic HC-exosomal mechanisms in vivo [PMC8607138]. The microRNA is also involved in the regulation of the Nrf2 pathway, which is crucial for cellular defense mechanisms, by binding to Nrf2 through multiple distinct sites when co-existing with other miRs [PMC3517581]. Genetic variants within MIR27A have been studied for their association with the risk of coronary artery disease (CAD), highlighting its potential role in cardiovascular conditions [PMC9141586]. Furthermore, MIR27A is suggested to have a regulatory role in both stem cell and adipocyte differentiation processes [PMC6158720]'>PMC6158720], and its overexpression has been observed to inhibit the migration of preadipocytes [PMC6158720]. The microRNA also interacts with key transcription factors and signaling pathways by regulating Sp1 repressors involved in the expression of VEGF and VEGFR1 [PMC7168141]. Lastly, despite a reduced level of Dicer enzyme which is crucial for miRNA maturation, overexpression of MIR27A has been observed in Treg cells from MRL/lpr mice models [PMC3072673], indicating its potential regulatory role within the immune system.
Literature search
380 open access papers mention hsa-mir-27a
(2322 sentences)
(2322 sentences)
Sequence
556854
reads,
3484
reads per million, 150 experiments
cugaggagcAGGGCUUAGCUGCUUGUGAGCAggguccacaccaagucgugUUCACAGUGGCUAAGUUCCGCcccccag
(((.((.((.(((((((((((((.(((((((.((.(........))).)))))))))))))))))))).)).)).)))
(((.((.((.(((((((((((((.(((((((.((.(........))).)))))))))))))))))))).)).)).)))
Structure
a a A U g u cac cug gg gc GGGCUUAGCUGCU GUGAGCA gg c a ||| || || ||||||||||||| ||||||| || | gac cc CG CUUGAAUCGGUGA CACUUgu cu g c c c C - g - aac
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA was previously named miR-27 [1,2] but is renamed here to avoid confusion with the more recently described miR-27b (MIR:MI0000440).
Genome context
chr19: 13836440-13836517 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-27a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-27a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-27a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-27a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-27a-5p
| Accession | MIMAT0004501 |
| Description | Homo sapiens hsa-miR-27a-5p mature miRNA |
| Sequence | 10 - AGGGCUUAGCUGCUUGUGAGCA - 31 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-27a-3p
| Accession | MIMAT0000084 |
| Description | Homo sapiens hsa-miR-27a-3p mature miRNA |
| Sequence | 51 - UUCACAGUGGCUAAGUUCCGC - 71 |
| Evidence |
experimental
cloned [1,3-5], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
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