Accession
MI0000086
Symbol
HGNC:
MIR28
Description
Homo sapiens
hsa-mir-28 precursor miRNA mir-28
Gene
family?
family?
RF00655;
mir-28
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
hsa-mir-28 is a microRNA that has been identified as one of several miRNAs overexpressed in resting CD4+ T cells, which target the 3' end of the HIV-1 RNA, leading to the silencing of viral protein transcription [PMC4070032]. This miRNA has also been observed to have lower expression levels in monomorphic malignant ventricular premature contractions (MMVP) specimens compared to focal ectopic dysplasia (FED) samples, suggesting a potential role in cardiac conditions [PMC4881574]. Studies on hsa-mir-28-5p, a specific variant of hsa-mir-28, have shown that it generally exerts an inhibitory effect on tumor cells in vitro [PMC8752235]. Furthermore, hsa-mir-28 is part of a group that includes the hsa-miR-548 family and is derived from genetic elements that contribute to its expression and function [PMC2952848]. Despite its involvement in various biological processes and conditions, hsa-mir-28 has been identified as one of the less frequently highly expressed miRNAs in certain contexts [PMC4486185].
Literature search
90 open access papers mention hsa-mir-28
(309 sentences)
(309 sentences)
Sequence
150537
reads,
1128
reads per million, 158 experiments
gguccuugcccucAAGGAGCUCACAGUCUAUUGAGuuaccuuucugacuuuccCACUAGAUUGUGAGCUCCUGGAgggcaggcacu
(((.(((((((((.((((((((((((((((.(((((((......)))))....)).)))))))))))))))).))))))))).)))
(((.(((((((((.((((((((((((((((.(((((((......)))))....)).)))))))))))))))).))))))))).)))
Structure
c A U ---- cc ggu cuugcccuc AGGAGCUCACAGUCUA UG AGuua u ||| ||||||||| |||||||||||||||| || ||||| uca ggacgggAG UCCUCGAGUGUUAGAU AC ucagu u c G C ccuu cu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr3: 188688781-188688866 [+]
Disease association
hsa-mir-28 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-28-5p
| Accession | MIMAT0000085 |
| Description | Homo sapiens hsa-miR-28-5p mature miRNA |
| Sequence | 14 - AAGGAGCUCACAGUCUAUUGAG - 35 |
| Evidence |
experimental
cloned [1-3], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-28-3p
| Accession | MIMAT0004502 |
| Description | Homo sapiens hsa-miR-28-3p mature miRNA |
| Sequence | 54 - CACUAGAUUGUGAGCUCCUGGA - 75 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
References
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