Accession
MI0000088
Symbol
HGNC:
MIR30A
Description
Homo sapiens
hsa-mir-30a precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR30A is a type of microRNA that plays a role in various cellular processes [PMC6888542]. Targeting MIR30A has been shown to decrease autophagy and increase sensitivity to Imatinib in primary LMC cells [PMC6888542]. The human MIR30A loop sequence (MIR30Ahsp) has been chosen for its high expression of siRNAs [PMC2737240]. Inhibition of exosomal MIR30A has been found to attenuate the protective effect of EGCG in hypoxic injury [PMC7054242]. The miR-30 family members, including MIR30A, are encoded on different chromosomes in clustered pairs [PMC4873751]. In a study, the expression of various genes was found to be affected by MIR30A, including both upregulated and downregulated genes [PMC7260613]. Specifically, miR7b and MIR30A were found to target the unique OCs-specific fusogen DC-STAMP [PMC7504439].
Literature search
486 open access papers mention hsa-mir-30a
(2535 sentences)
(2535 sentences)
Sequence
4160938
reads,
5468
reads per million, 158 experiments
gcgacUGUAAACAUCCUCGACUGGAAGcugugaagccacagaugggCUUUCAGUCGGAUGUUUGCAGCugc
(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).)))
(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).)))
Structure
a UC ----- a gcg cUGUAAACAUCC GACUGGAAGcu gug a ||| |||||||||||| ||||||||||| ||| cgu GACGUUUGUAGG CUGACUUUCgg cac g C -- guaga c
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequences miR-30 [1] and miR-97 [2] appear to originate from the same precursor. Subsequent data confirm that both arms of the precursor appear to give rise to mature miRNA sequences (Pfeffer S, pers. comm.). Landgraf et al. later showed that the 5' product is the predominant one [5]. Related miRNAs are processed from the 5' arms of other precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736; mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
Genome context
chr6: 71403551-71403621 [-]
Disease association
hsa-mir-30a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-30a-5p
| Accession | MIMAT0000087 |
| Description | Homo sapiens hsa-miR-30a-5p mature miRNA |
| Sequence | 6 - UGUAAACAUCCUCGACUGGAAG - 27 |
| Evidence |
experimental
cloned [2,4-6] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-30a-3p
| Accession | MIMAT0000088 |
| Description | Homo sapiens hsa-miR-30a-3p mature miRNA |
| Sequence | 47 - CUUUCAGUCGGAUGUUUGCAGC - 68 |
| Evidence |
experimental
cloned [1,4-5], Northern [1] |
| Database links |
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| Predicted targets |
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References
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