miRBase entry: hsa-mir-31

Stem-loop hsa-mir-31

Homo sapiens hsa-mir-31 precursor miRNA
Gene family
MIPF0000064; mir-31

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR31 is a microRNA that has been shown to act as a tumor suppressor when transferred to HepG2 and primary hepatocarcinoma cells by HLSC-EVs [PMC8107725]. It is believed that MIR31 represses the expression of tumor suppressor genes, such as LATS2, and indirectly promotes the transcription of genes related to cell cycle control and tumorigenesis [PMC4067122]. Researchers have investigated the potential of modulating MIR31 using morpholino oligomers in a dystrophic context [PMC4972457]. MIR31, along with miR17-3p, has been found to regulate the expression of E-selectins and ICAM-1, reducing neutrophil adhesion and post-stroke leukocyte infiltration [PMC6732937]. Specific primers were used for amplifying MIR31 in experiments [PMC8906324]. It has been suggested that infected cells modulate the expression of certain microRNAs, including MIR31, which sustains CIITA expression [PMC9591123]. The MIR31 locus generates both MIR31 and a long non-coding RNA (lnc-MIR31) via mutually exclusive pathways [PMC4972457]. Comparison of all MIR31 outliers with non-outliers showed that MIR31 outliers were most similar to CMS4-mesenchymals in terms of biological characteristics [PMC6590447]. Additionally, WAVE3-targeting microRNAs provide further support for the function of WAVE3 as a metastasis-promoter gene [PMC3428347].

Literature search
385 open access papers mention hsa-mir-31
(2789 sentences)


61511 reads, 2296 reads per million, 128 experiments

       A     G   C         -U   gaa 
ggagagg GGCAA AUG UGGCAUAGC  guu   c
||||||| ||||| ||| |||||||||  |||    
ccuuucU CCGUU UAC ACCGUAUCG  caa   u
       A     A   A         Uc   ggg 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr9: 21512115-21512185 [-]

Disease association
hsa-mir-31 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-31-5p

Accession MIMAT0000089
Description Homo sapiens hsa-miR-31-5p mature miRNA
Evidence experimental
cloned [1-3], Northern [1]
Database links
Predicted targets

Mature hsa-miR-31-3p

Accession MIMAT0004504
Description Homo sapiens hsa-miR-31-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043