Accession
MI0000093
Symbol
HGNC:
MIR92A1
Description
Homo sapiens
hsa-mir-92a-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR92A1 is a microRNA that is part of the miR-17~92 cluster, which is encoded by the MIR17HG host gene and includes several other miRNAs such as MIR17, MIR18A, MIR19A, MIR20A, and MIR19B1 [PMC4005632]. This cluster has been found to be upregulated in Alzheimer's disease (AD), with a specific increase in the expression of MIR92A1 observed in the cortex of AD patients [PMC7564652]. The upregulation of miRNAs including MIR92A1 has been linked to the downregulation of their target genes in disease models [PMC6321611]. The role of these miRNAs in AD is complex and not fully understood; however, it has been suggested that MIR92A1 may be involved in memory processes [PMC7564652]. Additionally, a microduplication encompassing the miR-17~92 cluster genes suggests a potential genetic basis for their altered expression levels [PMC4005632]. The conservation of a p53 binding site within the human MIR92A1 locus indicates potential regulatory mechanisms that may be important for its expression and function [PMC9207587].
Literature search
361 open access papers mention hsa-mir-92a-1
(1567 sentences)
(1567 sentences)
Sequence
1747087
reads,
5716
reads per million, 158 experiments
cuuucuacacAGGUUGGGAUCGGUUGCAAUGCUguguuucuguauggUAUUGCACUUGUCCCGGCCUGUugaguuugg
....((..((((((((((((.(((.(((((((((((......)))))))))))))).))))))))))))..)).....
....((..((((((((((((.(((.(((((((((((......)))))))))))))).))))))))))))..)).....
Structure
-cuuu ac C U uu
cu acAGGUUGGGAU GGU GCAAUGCUgug u
|| |||||||||||| ||| |||||||||||
ga UGUCCGGCCCUG UCA CGUUAUgguau c
gguuu gu U - gu
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
Human miR-92a (previously named miR-92 here) has two predicted hairpin precursor sequences: mir-92a-1 (MIR:MI0000093) on chromosome 13 (named mir-92-13 in [1]) and mir-92a-2 (MIR:MI0000094) on chromosome X (named mir-92-X in [1]). miR-92a has also been cloned from mouse embryonic stem cells [2] and is predicted to be expressed from two closely related precursor hairpins (MIR:MI0000719 and MIR:MI0000580). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [7].
Genome context
chr13: 91351314-91351391 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-92a-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-92a-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-92a-1-5p
| Accession | MIMAT0004507 |
| Description | Homo sapiens hsa-miR-92a-1-5p mature miRNA |
| Sequence | 11 - AGGUUGGGAUCGGUUGCAAUGCU - 33 |
| Evidence |
experimental
cloned [7-8] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-92a-3p
| Accession | MIMAT0000092 |
| Description | Homo sapiens hsa-miR-92a-3p mature miRNA |
| Sequence | 48 - UAUUGCACUUGUCCCGGCCUGU - 69 |
| Evidence |
experimental
cloned [1,3,5-8], Northern [4] |
| Database links |
|
| Predicted targets |
|
References
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