miRBase entry: hsa-mir-92a-1

Stem-loop hsa-mir-92a-1

Homo sapiens hsa-mir-92a-1 precursor miRNA
Gene family
MIPF0000013; mir-25

Caution, this is an AI generated summary based on literature. This may have errors. ?

Investigating the locus revealed that the miR17-92 cluster, which includes MIR17, MIR18A, MIR19A, MIR20A, MIR19B1, and MIR92A1, is affected by copy gains or amplifications [PMC9259584]. In Alzheimer's disease (AD), MIR199A2, MIR218-2, MIR24-2, MIR92A1, and MIR99A were found to be upregulated, while MIR129-2, MIR1296, MIR219A1, MIR29B1, MIR375, MIR411, and MIR431 were downregulated [PMC7564652]. The targets of MIR199A2, MIR219A1, MIR24-2, MIR375, MIR411, and MIR92A1 are known, but their role in AD is not clear [PMC7564652]. Dysregulation of several miRNAs, including MIR29B1, MIR129-2, MIR219A1, MIR199A2, MIR92A1, and MIR1296, has been observed in AD patients [PMC7564653][PMC632161][PMC400563][PMC959924[PMC632161][PMC400563][PMC959924]. The miR17-92 cluster has been found to be upregulated in both medaka and human melanoma models [PMC6321611]. A microduplication at 13q31.3 was detected, which encompassed the miR-17 ~ 92 cluster genes and the first five exons of the GPC5 gene [PMC4005632]. A p53 binding site in the human MIR92A1 locus was also identified [PMC9207587].

Literature search
361 open access papers mention hsa-mir-92a-1
(1567 sentences)


1747566 reads, 7474 reads per million, 158 experiments

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Annotation confidence High
Do you think this miRNA is real?
Human miR-92a (previously named miR-92 here) has two predicted hairpin precursor sequences: mir-92a-1 (MIR:MI0000093) on chromosome 13 (named mir-92-13 in [1]) and mir-92a-2 (MIR:MI0000094) on chromosome X (named mir-92-X in [1]). miR-92a has also been cloned from mouse embryonic stem cells [2] and is predicted to be expressed from two closely related precursor hairpins (MIR:MI0000719 and MIR:MI0000580). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [7].

Genome context
chr13: 91351314-91351391 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-92a-1
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-92a-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-92a-1-5p

Accession MIMAT0004507
Description Homo sapiens hsa-miR-92a-1-5p mature miRNA
Evidence experimental
cloned [7-8]
Database links
Predicted targets

Mature hsa-miR-92a-3p

Accession MIMAT0000092
Description Homo sapiens hsa-miR-92a-3p mature miRNA
Evidence experimental
cloned [1,3,5-8], Northern [4]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  6. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728

  7. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  8. PubMed ID: 12919684
    Embryonic stem cell-specific MicroRNAs
    "Houbaviy HB, Murray MF, Sharp PA"
    "Dev Cell (2003) 5:351-358