miRBase entry: hsa-mir-98

Stem-loop hsa-mir-98

Homo sapiens hsa-mir-98 precursor miRNA
Gene family
MIPF0000002; let-7

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR98 is a microRNA that has been implicated in breast cancer metastasis [PMC4653020]. In a study conducted on nude mice, MDA-MB-231 breast cancer cells infected with lentivirus carrying either MIR98 or a control (NC) were stimulated with CCL18, and their metastatic potential was evaluated [PMC4653020]. Among several microRNAs, including miR-18a, miR-21, miR-26a, miR-26b, miR-30b, MIR98 and miR-210, MIR98 was selected for further validation using Taqman quantitative RT-PCR [PMC3288043]. The study also found that when N-Ras is silenced in breast cancer cells, the ERK/PI3K/NFκB/Lin28b pathway is inactivated. This inactivation leads to the loss of Lin28b as an inhibitor of MIR98 and subsequently results in higher levels of MIR98. The increased levels of MIR98 further inhibit the expression of N-Ras [PMC4653020]. These findings suggest that reduction in MIR98 expression may contribute to enhanced breast cancer metastasis when stimulated by CCL18 [PMC4653020].

Literature search
137 open access papers mention hsa-mir-98
(565 sentences)


58305 reads, 616 reads per million, 132 experiments

a    uc    -          U                 U    ---------      aggg 
 ggau  ugcu caugccaggg GAGGUAGUAAGUUGUAU GUUg         uggggu    a
 ||||  |||| |||||||||| ||||||||||||||||| ||||         ||||||    u
 cuua  acgg gugugguCCC UUUCAUCAUUCAACAUA Caau         accccg    a
a    -u    u          -                 U    agaagauua      gauu 

Annotation confidence High
Do you think this miRNA is real?
This sequence is localised to chromosome X and was named mir-98-X in reference [1]. The predicted stem-loop precursor sequence is clearly related to let-7.

Genome context
chrX: 53556223-53556341 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-98
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-98 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-98 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-98 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-98-5p

Accession MIMAT0000096
Description Homo sapiens hsa-miR-98-5p mature miRNA
Evidence experimental
cloned [1-3], SOLiD [4]
Database links
Predicted targets

Mature hsa-miR-98-3p

Accession MIMAT0022842
Description Homo sapiens hsa-miR-98-3p mature miRNA
Evidence experimental
SOLiD [4]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728

  4. PubMed ID: 22282338
    Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
    "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
    "RNA (2012) 18:472-484