Stem-loop hsa-mir-99a

Accession

MI0000101

Symbol

HGNC: MIR99A

Description

Homo sapiens hsa-mir-99a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR99A is a microRNA that has been identified as a regulator of NOX4 expression by targeting the 3’-UTR [PMC7407884]. This microRNA is notably one of the most elevated plasma miRNAs in community-acquired pneumonia (CAP), suggesting its potential role in the pathophysiology or as a biomarker for this condition [PMC8358855].

Literature search

196 open access papers mention hsa-mir-99a
(1198 sentences)

Sequence

393619 reads, 1375 reads per million, 159 experiments

cccauuggcauaAACCCGUAGAUCCGAUCUUGUGgugaaguggaccgcaCAAGCUCGCUUCUAUGGGUCUGugucagugug
..((((((((((.(((((((((..(((.((((((.((........)))))))).)))..))))))))).))))))))))..

Structure

cc          A         UC   U      g  aag 
  cauuggcaua ACCCGUAGA  CGA CUUGUG ug   u
  |||||||||| |||||||||  ||| |||||| ||    
  gugacuguGU UGGGUAUCU  GCU GAACac gc   g
gu          C         UC   C      -  cag 

Annotation confidence High

Comments

This sequence is localised to chromosome 21 and was named mir-99-21 in reference [1].

Genome context

chr21: 16539089-16539169 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-99a

Disease association

hsa-mir-99a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-99a-5p

• Accession: MIMAT0000097
• Description: Homo sapiens hsa-miR-99a-5p mature miRNA
• Sequence: 13 - AACCCGUAGAUCCGAUCUUGUG - 34
• Evidence: experimental ; cloned [1-3]

Mature hsa-miR-99a-3p

• Accession: MIMAT0004511
• Description: Homo sapiens hsa-miR-99a-3p mature miRNA
• Sequence: 50 - CAAGCUCGCUUCUAUGGGUCUG - 71
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 11914277
   miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
   "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
   "Genes Dev (2002) 16:720-728