Accession
MI0000105
Symbol
HGNC:
MIR29B1
Description
Homo sapiens
hsa-mir-29b-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR29B1 is a microRNA that has been observed to be downregulated in Alzheimer's disease (AD) patients [PMC7564652]. It has been found to target secretases, which are involved in AD pathogenesis, as well as have a protective effect on neuron survival [PMC7564652]. Additionally, MIR29B1 has been shown to regulate BACE1 expression, a gene involved in AD, in vitro [PMC7564652]. In the cortex of AD patients, MIR29B1 is downregulated along with other microRNAs such as MIR129-2, MIR1296, MIR219A1, MIR375, MIR411, and MIR431 [PMC7564652]. Conversely, microRNAs such as MIR199A2 and MIR92A1 are upregulated in the cortex of AD patients [PMC7564652]. In other contexts, such as dairy cattle domestication and breast cancer cells (MDA-MB-231S), upregulation of MIR29B1 has been observed [PMC6898964] [PMC4651668]. It is also a host gene for miR-22 and miR-29b which are downregulated in certain diseases like SMZL (splenic marginal zone lymphoma) [PMC7111612] [PMC8064455]. In rats with a homozygous mutation of the Mir29b-1/a gene that encodes nucleotides 6–9 in the sequence of mature miR-29b-3p (MIR29B1), reduced urine volume and urinary sodium excretion were observed due to reduced NO levels in the renal outer medulla [PMC6156712].
Literature search
661 open access papers mention hsa-mir-29b-1
(4447 sentences)
(4447 sentences)
Sequence
369151
reads,
2447
reads per million, 159 experiments
cuucaggaaGCUGGUUUCAUAUGGUGGUUUAGAuuuaaauagugauugucUAGCACCAUUUGAAAUCAGUGUUcuuggggg
(((((((((((((((((((.((((((..((((((.............)))))))))))).)))))))))).))))))))).
(((((((((((((((((((.((((((..((((((.............)))))))))))).)))))))))).))))))))).
Structure
- - U GU uuaaa cuucaggaa GCUGGUUUCA AUGGUG UUAGAu u ||||||||| |||||||||| |||||| |||||| a gggguucUU UGACUAAAGU UACCAC GAUcug g g G U -- uuagu
Annotation confidence
High
Do you think this miRNA is real?
Comments
Mourelatos et al. identified two copies of this sequence mapping to chromosome 7, and assigned the names mir-102-7.1 and mir-102-7.2 [1]. Subsequent genome assemblies suggest the presence of only one miR-102 locus on chromosome 7. Human miR-102 is a homologue of mouse miR-29b (MIR:MI0000143) and so has been renamed here for consistency.
Genome context
chr7: 130877459-130877539 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-29b-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-29b-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-29b-1-5p
| Accession | MIMAT0004514 |
| Description | Homo sapiens hsa-miR-29b-1-5p mature miRNA |
| Sequence | 10 - GCUGGUUUCAUAUGGUGGUUUAGA - 33 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-29b-3p
| Accession | MIMAT0000100 |
| Description | Homo sapiens hsa-miR-29b-3p mature miRNA |
| Sequence | 51 - UAGCACCAUUUGAAAUCAGUGUU - 73 |
| Evidence |
experimental
cloned [1-4], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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