Accession
MI0000120
Description
Drosophila melanogaster
dme-mir-2b-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Dme-mir-2b is a member of the miR-2 family in Drosophila, with its mature sequence being one nucleotide longer than previously annotated in miRBase [PMC3268580]. The specific roles of dme-mir-2b in Drosophila development and physiology are not yet fully understood [PMC9100521]. However, overexpression of dme-mir-2b using the Act-Gal4 driver leads to almost complete lethality, indicating its significant role during embryogenesis and development [PMC9100521]. Additionally, overexpression experiments using Pdf-Gal4 suggest that dme-mir-2b is crucial for the photoperiodic response, with alterations in expression levels affecting diapause [PMC9100521]. Dme-mir-2b is one of seven miRNAs found to be differentially expressed between long and short photoperiods, with higher expression levels during longer days [PMC9100521].
Literature search
29 open access papers mention dme-mir-2b-2
(120 sentences)
(120 sentences)
Sequence
532664
reads,
9405
reads per million, 49 experiments
uugugucaUUCUUCAAAGUGGUUGUGAAAUGuuugccuuuuuaugccuauucaUAUCACAGCCAGCUUUGAGGAGCgacgcga
(((((((.(((((((((((((((((((.(((...((........)).....))).))))))))).)))))))))).)))))))
(((((((.(((((((((((((((((((.(((...((........)).....))).))))))))).)))))))))).)))))))
Structure
a - A --uuu cuu
uuguguc UUCUUCAAAG UGGUUGUGA AUG gc u
||||||| |||||||||| ||||||||| ||| ||
agcgcag GAGGAGUUUC ACCGACACU Uac cg u
C G A uuauc uau
Annotation confidence
High
Do you think this miRNA is real?
Comments
Stark et al. [2] have identified targets for miR-2 in Drosophila using computational prediction followed by experimental validation. miR-2 regulates the proapoptotic genes reaper, grim and sickle, suggesting that it may be involved in the control of apoptosis.
Genome context
chr2L: 19570182-19570264 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-2b-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature dme-miR-2b-3p
| Accession | MIMAT0000107 |
| Description | Drosophila melanogaster dme-miR-2b-3p mature miRNA |
| Sequence | 54 - UAUCACAGCCAGCUUUGAGGAGC - 76 |
| Evidence |
experimental
cloned [1,4], Northern [1,3], 454 [5-6], Illumina [6] |
| Database links |
|
| Predicted targets |
|
Mature dme-miR-2b-2-5p
| Accession | MIMAT0020783 |
| Description | Drosophila melanogaster dme-miR-2b-2-5p mature miRNA |
| Sequence | 9 - UUCUUCAAAGUGGUUGUGAAAUG - 31 |
| Evidence | not_experimental |
| Database links |
|
References
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