Stem-loop dme-mir-7

Accession

MI0000127

Description

Drosophila melanogaster dme-mir-7 precursor miRNA

Literature search

31 open access papers mention dme-mir-7
(265 sentences)

Sequence

501109 reads, 4215 reads per million, 49 experiments

gagugcauuccguaUGGAAGACUAGUGAUUUUGUUGUuuggucuuugguaauaaCAAUAAAUCCCUUGUCUUCUUAcggcgugcauuu
((((((((.(((((.(((((((.((.(((((.((((((....(....)....))))))))))).)).)))))))))))).))))))))

Structure

        u     U       U  U     U      uggu u 
gagugcau ccgua GGAAGAC AG GAUUU GUUGUu    c u
|||||||| ||||| ||||||| || ||||| ||||||    |  
uuuacgug ggcAU UCUUCUG UC CUAAA UAACaa    g u
        c     -       U  C     -      uaau g 

Annotation confidence High

Comments

Stark et al. [2] have identified targets for miR-7 in Drosophila using computational prediction followed by experimental validation. miR-7 regulates a family of Notch targets including the Enhancer of split and Bearded complex genes Tom and m4, and the basic helix-loop-helix transcriptional repressors HLHm3 and hairy.

Genome context

chr2R: 20606067-20606154 [+]

Mature dme-miR-7-5p

• Accession: MIMAT0000112
• Description: Drosophila melanogaster dme-miR-7-5p mature miRNA
• Sequence: 15 - UGGAAGACUAGUGAUUUUGUUGU - 37
• Evidence: experimental ; cloned [1,4], Northern [1,3-4], 454 [5-6], Illumina [6]

Mature dme-miR-7-3p

• Accession: MIMAT0020790
• Description: Drosophila melanogaster dme-miR-7-3p mature miRNA
• Sequence: 55 - CAAUAAAUCCCUUGUCUUCUUA - 76
• Evidence: not_experimental

References

1. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


2. PubMed ID: 12812784
   Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
   "Sempere LF, Sokol NS, Dubrovsky EB, Berger EM, Ambros V"
   "Dev Biol (2003) 259:9-18


3. PubMed ID: 12919683
   The small RNA profile during Drosophila melanogaster development
   "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
   "Dev Cell (2003) 5:337-350


4. PubMed ID: 17989254
   Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
   "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
   "Genome Res (2007) 17:1850-1864


5. PubMed ID: 17989255
   Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
   "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
   "Genome Res (2007) 17:1865-1879


6. PubMed ID: 14691535
   Identification of Drosophila MicroRNA targets
   "Stark A, Brennecke J, Russell RB, Cohen SM"
   "PLoS Biol (2003) 1:E60