Stem-loop mmu-mir-136

Accession

MI0000162

Symbol

MGI: Mir136

Description

Mus musculus mmu-mir-136 precursor miRNA mir-136

Gene
family

RF00687; mir-136

Literature search

24 open access papers mention mmu-mir-136
(149 sentences)

Sequence

323268 reads, 2089 reads per million, 85 experiments

gaggACUCCAUUUGUUUUGAUGAUGGauucuuaagcuccAUCAUCGUCUCAAAUGAGUCUUc
((((((((.(((((...((((((((((.........))))))))))...)))))))))))))

Structure

        C     UUU          uuc 
gaggACUC AUUUG   UGAUGAUGGa   u
|||||||| |||||   ||||||||||   u
cUUCUGAG UAAAC   GCUACUAccu   a
        -     UCU          cga 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr12: 109595327-109595388 [+]

Clustered miRNAs

12 other miRNAs are < 10 kb from mmu-mir-136

Mature mmu-miR-136-5p

• Accession: MIMAT0000148
• Description: Mus musculus mmu-miR-136-5p mature miRNA
• Sequence: 5 - ACUCCAUUUGUUUUGAUGAUGG - 26
• Evidence: experimental ; cloned [1-2,4], PCR [3], Illumina [5-6]

Mature mmu-miR-136-3p

• Accession: MIMAT0004532
• Description: Mus musculus mmu-miR-136-3p mature miRNA
• Sequence: 40 - AUCAUCGUCUCAAAUGAGUCUU - 61
• Evidence: experimental ; cloned [4], Illumina [5-6]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


6. PubMed ID: 15854907
   RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus
   "Davis E, Caiment F, Tordoir X, Cavaille J, Ferguson-Smith A, Cockett N, Georges M, Charlier C"
   "Curr Biol (2005) 15:743-749