Stem-loop mmu-mir-190a

Accession

MI0000232

Symbol

MGI: Mir190a

Description

Mus musculus mmu-mir-190a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Mmu-mir-190 is a microRNA that was found to be significantly downregulated in the corneal endothelium of old mice compared to young mice [PMC3742134]. The expression of mmu-mir-190 was decreased by 37.1±2.78-fold in old mice [PMC3742134]. The miRNA-mRNA regulatory network analysis revealed that mmu-mir-190 is associated with brain-derived neurotrophic factor (BDNF) [PMC3742134]. In addition to mmu-mir-190, several other miRNAs were also found to be downregulated in the corneal endothelium of old mice, including mmu-miR-31, mmu-miR-455, mmu-miR-744, mmu-miR-695, mmu-miR-181a, mmu-miR-181d, mmu-miR-182, and mmu-miR-194 [PMC3742134'>PMC3742134'>PMC3742134'>PMC3742134]. On the other hand, miRNAs such as mmu-miR-34c and mmu-miR124 were significantly upregulated in old mice compared to young mice [PMC3742134]. The downregulation of these miRNAs suggests a potential role in age-related changes in the corneal endothelium. To validate the results from the miRNA microarray analysis, qRT-PCR was performed for several miRNAs including mmu mir 190 using the same extracted total RNA as the microarray analysis [PMC3742134]. The qRT PCR results confirmed the downregulation of these miRNAs in old mice compared to young mice [PMC3742134]. Overall, these findings suggest that changes in expression levels of specific miRNAs including Mmu mir 190 may contribute to age-related alterations in corneal endothelial function [PMC3742134].

Literature search

19 open access papers mention mmu-mir-190a
(59 sentences)

Sequence

14711 reads, 182 reads per million, 71 experiments

cugugUGAUAUGUUUGAUAUAUUAGGUuguuauuuaauccaACUAUAUAUCAAGCAUAUUCCUacag
(((((.((((((((((((((((..(((((..........)))))))))))))))))))))..)))))

Structure

     -U                UA     uuau 
cugug  GAUAUGUUUGAUAUAU  GGUug    u
|||||  ||||||||||||||||  |||||     
gacaU  UUAUACGAACUAUAUA  UCAac    u
     CC                --     cuaa 

Annotation confidence High

Genome context

chr9: 67236660-67236726 [-]

Mature mmu-miR-190a-5p

• Accession: MIMAT0000220
• Description: Mus musculus mmu-miR-190a-5p mature miRNA
• Sequence: 6 - UGAUAUGUUUGAUAUAUUAGGU - 27
• Evidence: experimental ; cloned [1-2], Illumina [4]

Mature mmu-miR-190a-3p

• Accession: MIMAT0016998
• Description: Mus musculus mmu-miR-190a-3p mature miRNA
• Sequence: 42 - ACUAUAUAUCAAGCAUAUUCCU - 63
• Evidence: experimental ; 454 [3], Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 20668074
   Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68
   "Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H"
   "J Virol (2010) 84:10266-10275