Accession
MI0000239
Symbol
HGNC:
MIR197
Description
Homo sapiens
hsa-mir-197 precursor miRNA mir-197
Gene
family?
family?
RF00707;
mir-197
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR197 is a microRNA that has been detected to change its expression in response to resistance training [PMC8505326]. It is one of several miRNAs that show immediate, 1-hour, 4-hour, and 24-hour changes in expression after a single bout of resistance training [PMC8505326]. MIR197 has been found to be inversely related to PD-L1 expression in acute myeloid leukemia, NSCLC, biliary epithelial cells, hepatocellular carcinoma, and colon cancer [PMC7529545]. It is considered a potential surrogate biomarker for PD-L1 expression in NSCLC [PMC7529545]. MIR197 levels have also been measured in sera using quantitative real-time polymerase chain reaction (PCR) [PMC7414326]. In the context of insulin resistance and glucose homeostasis, there appears to be an inverse correlation between glycemia and hepatic levels of MIR197 [PMC6197154]. MIR197 plays an important role in the maintenance of embryogenic callus in rice [PMC10049443]. In female breast cancer, up-regulation of MIR197 has not been reported so far [PMC2850898]. Changes in the levels of MIR197 have also been associated with metabolic syndrome [PMC8793096]. The DDB2 SNP rs1050244 may interfere with the targeted interaction between miR-133a and MIR197, resulting in upregulation of DDB2 mRNA expression and reduced susceptibility to HCC [PMC9712371]. Gap junction-transferred microRNAs including MIR197 have been shown to reduce cancer cell proliferation and induce dormancy that may lead to bone marrow metastasis relapse [PMC4699086].
Literature search
71 open access papers mention hsa-mir-197
(290 sentences)
(290 sentences)
Sequence
35297
reads,
379
reads per million, 117 experiments
ggcugugcCGGGUAGAGAGGGCAGUGGGAGGuaagagcucuucacccUUCACCACCUUCUCCACCCAGCauggcc
((((((((.((((.(((((((..(((((.((((((....))).))).)))))..))))))).)))).))))))))
((((((((.((((.(((((((..(((((.((((((....))).))).)))))..))))))).)))).))))))))
Structure
C A CA A - a
ggcugugc GGGU GAGAGGG GUGGG GGu aag g
|||||||| |||| ||||||| ||||| ||| |||
ccgguaCG CCCA CUCUUCC CACUU cca uuc c
A C AC c c u
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr1: 109598893-109598967 [+]
Disease association
hsa-mir-197 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-197-3p
| Accession | MIMAT0000227 |
| Description | Homo sapiens hsa-miR-197-3p mature miRNA |
| Sequence | 48 - UUCACCACCUUCUCCACCCAGC - 69 |
| Evidence |
experimental
cloned [1-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-197-5p
| Accession | MIMAT0022691 |
| Description | Homo sapiens hsa-miR-197-5p mature miRNA |
| Sequence | 9 - CGGGUAGAGAGGGCAGUGGGAGG - 31 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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