Stem-loop hsa-mir-30c-2

Accession

MI0000254

Symbol

HGNC: MIR30C2

Description

Homo sapiens hsa-mir-30c-2 precursor miRNA

Literature search

381 open access papers mention hsa-mir-30c-2
(1903 sentences)

Sequence

298037 reads, 1054 reads per million, 158 experiments

agauacUGUAAACAUCCUACACUCUCAGCuguggaaaguaagaaagCUGGGAGAAGGCUGUUUACUCUuucu
(((....(((((((.(((...(((((((((..............))))))))).))).)))))))....)))

Structure

   uacU       U   ACA         guggaa 
aga    GUAAACA CCU   CUCUCAGCu      a
|||    ||||||| |||   |||||||||       
ucu    CAUUUGU GGA   GAGGGUCga      g
   uUCU       C   --A         aagaau 

Annotation confidence High

Comments

miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana et al. [1]. Two human hairpin precursor sequences are predicted based on homology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6 (MIR:MI0000254) [3]. Expression of miR-30c was later independently verified in human HL-60 leukemia cells [2].

Genome context

chr6: 71376960-71377031 [-]

Disease association

hsa-mir-30c-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-30c-5p

• Accession: MIMAT0000244
• Description: Homo sapiens hsa-miR-30c-5p mature miRNA
• Sequence: 7 - UGUAAACAUCCUACACUCUCAGC - 29
• Evidence: experimental ; cloned [2,4-6]

Mature hsa-miR-30c-2-3p

• Accession: MIMAT0004550
• Description: Homo sapiens hsa-miR-30c-2-3p mature miRNA
• Sequence: 47 - CUGGGAGAAGGCUGUUUACUCU - 68
• Evidence: experimental ; cloned [5]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


5. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73