Accession
MI0000254
Symbol
HGNC:
MIR30C2
Description
Homo sapiens
hsa-mir-30c-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR30C2 is a gene encoding a microRNA involved in regulatory processes, located on chromosome 6q13 [PMC5400605]. It is part of the miR-30c cluster, which has been observed to undergo deletions in various cases of genomic alterations, with MIR30C2 specifically being deleted in 32% (13 out of 41) of the samples studied [PMC5400605]. The regulatory potential of MIR30C2 has been highlighted by the identification of a TonE consensus sequence by Jaspar software, suggesting that TonEBP may influence its expression [PMC9104010]. Additionally, MIR30C2 is encompassed within the sequence of LINC00472, indicating that this long non-coding RNA could serve as the primary transcript for miR-30c [PMC9512191]. The gene has also been associated with negative correlations with COPZ1 expression in lung adenocarcinoma (LUAD) and interacts with various RNA and protein molecules as identified through research on NONO protein interactions [PMC10137353; PMC9730017].. Furthermore, a single nucleotide polymorphism (SNP) within MIR30C2 has been identified which could potentially impact its function [PMC9708458]. These findings underscore the significance of MIR30C2 in genomic stability and its potential role in gene regulation.
Literature search
381 open access papers mention hsa-mir-30c-2
(1903 sentences)
(1903 sentences)
Sequence
298038
reads,
1554
reads per million, 158 experiments
agauacUGUAAACAUCCUACACUCUCAGCuguggaaaguaagaaagCUGGGAGAAGGCUGUUUACUCUuucu
(((....(((((((.(((...(((((((((..............))))))))).))).)))))))....)))
(((....(((((((.(((...(((((((((..............))))))))).))).)))))))....)))
Structure
uacU U ACA guggaa aga GUAAACA CCU CUCUCAGCu a ||| ||||||| ||| ||||||||| ucu CAUUUGU GGA GAGGGUCga g uUCU C --A aagaau
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana et al. [1]. Two human hairpin precursor sequences are predicted based on homology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6 (MIR:MI0000254) [3]. Expression of miR-30c was later independently verified in human HL-60 leukemia cells [2].
Genome context
chr6: 71376960-71377031 [-]
Disease association
hsa-mir-30c-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-30c-5p
| Accession | MIMAT0000244 |
| Description | Homo sapiens hsa-miR-30c-5p mature miRNA |
| Sequence | 7 - UGUAAACAUCCUACACUCUCAGC - 29 |
| Evidence |
experimental
cloned [2,4-6] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-30c-2-3p
| Accession | MIMAT0004550 |
| Description | Homo sapiens hsa-miR-30c-2-3p mature miRNA |
| Sequence | 47 - CUGGGAGAAGGCUGUUUACUCU - 68 |
| Evidence |
experimental
cloned [5] |
| Database links |
|
| Predicted targets |
|
References
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