Stem-loop hsa-mir-30d

Accession

MI0000255

Symbol

HGNC: MIR30D

Description

Homo sapiens hsa-mir-30d precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR30D is a microRNA that plays a significant role in the regulation of human adipocyte development [PMC5701175]. In a study involving 136 matched samples from CSCC patients, the copy number variations (CNVs) of MIR30D were analyzed in both cancer tissues and adjacent normal tissues (ANTs) [PMC5372318]. This analysis is crucial as it helps to understand the genetic alterations associated with cancer progression. Furthermore, MIR30D has been found to have increased expression in patients with chronic thromboembolic obstruction (CTO) when compared to healthy individuals, indicating its potential involvement in pathological conditions beyond adipocyte development [PMC4558025]. This elevated expression of MIR30D, along with miR126, suggests that it may have diagnostic or therapeutic implications for CTO and possibly other diseases.

Literature search

380 open access papers mention hsa-mir-30d
(1570 sentences)

Sequence

1132297 reads, 2889 reads per million, 157 experiments

guuguUGUAAACAUCCCCGACUGGAAGcuguaagacacagcuaagCUUUCAGUCAGAUGUUUGCUGCuac
...((.(((((((((...(((((((((((..............))))))))))).))))))))).))...

Structure

guu  U         CCC           guaaga 
   gu GUAAACAUC   GACUGGAAGcu      c
   || |||||||||   |||||||||||       
   CG CGUUUGUAG   CUGACUUUCga      a
cau  U         --A           aucgac 

Annotation confidence High

Genome context

chr8: 134804876-134804945 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-30d

Mature hsa-miR-30d-5p

• Accession: MIMAT0000245
• Description: Homo sapiens hsa-miR-30d-5p mature miRNA
• Sequence: 6 - UGUAAACAUCCCCGACUGGAAG - 27
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-30d-3p

• Accession: MIMAT0004551
• Description: Homo sapiens hsa-miR-30d-3p mature miRNA
• Sequence: 46 - CUUUCAGUCAGAUGUUUGCUGC - 67
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 17989717
   Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
   "Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A"
   "Leukemia (2008) 22:330-338


4. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739