Stem-loop hsa-mir-181c

Accession

MI0000271

Symbol

HGNC: MIR181C

Description

Homo sapiens hsa-mir-181c precursor miRNA

Literature search

279 open access papers mention hsa-mir-181c
(1258 sentences)

Sequence

25355 reads, 107 reads per million, 130 experiments

cggaaaauuugccaaggguuugggggAACAUUCAACCUGUCGGUGAGUuugggcagcucaggcaAACCAUCGACCGUUGAGUGGACccugaggccuggaauugccauccu
.(((.......(((..(((((.((((..((((((((..(((((((.(((((...........)))))))))))).))))))))..)))).))))))))........))).

Structure

c   -aaauuug   ag     g    AA        CU       A     ggca 
 gga        cca  gguuu gggg  CAUUCAAC  GUCGGUG GUuug    g
 |||        |||  ||||| ||||  ||||||||  ||||||| |||||    c
 ccu        ggu  ccgga uccC  GUGAGUUG  CAGCUAC CAAac    u
u   accguuaa   --     g    AG        -C       -     ggac 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm the expression of miR-181c in human [2].

Genome context

chr19: 13874699-13874808 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-181c

Disease association

hsa-mir-181c is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-181c is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-181c is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-181c-5p

• Accession: MIMAT0000258
• Description: Homo sapiens hsa-miR-181c-5p mature miRNA
• Sequence: 27 - AACAUUCAACCUGUCGGUGAGU - 48
• Evidence: experimental ; cloned [2]

Mature hsa-miR-181c-3p

• Accession: MIMAT0004559
• Description: Homo sapiens hsa-miR-181c-3p mature miRNA
• Sequence: 65 - AACCAUCGACCGUUGAGUGGAC - 86
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540