Accession
MI0000274
Symbol
HGNC:
MIR187
Description
Homo sapiens
hsa-mir-187 precursor miRNA mir-187
Gene
family?
family?
RF00674;
mir-187
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR187 is a microRNA that is associated with the regulation of the potassium channel KCNK10/TREK-2 in a rat epilepsy model [PMC7041117]. It acts as a negative modulator of LPS responses by limiting TNF-α production and reducing IL-6 and IL-12p40 transcription [PMC5900789]. Through a complex network of miRNAs, MIR187 is upregulated by IL-10, which drives anti-inflammatory responses [PMC5900789]. In the context of recurrent pregnancy loss (RPL), MIR187 is significantly overexpressed in the villus of RPL women [PMC5572592]. It has also been identified as induced in RPL and suppressed in miR100, let7a, let7b, let7c, and miR21 [PMC4495342]. IL-10 has been shown to regulate the expression of MIR187 along with other miRNAs such as miR-155 and miR-146a/b [PMC5161420]. In immune infiltration studies, MIR187 expression levels were found to be highest in high-infiltrating groups compared to median-infiltrating and low-infiltrating groups [PMC7163112]. Additionally, MIR187 has been associated with immune responses along with other noncoding RNAs such as mir142, mir223, mir155, mir200a/b [PMC7163112]. Further research exploring the relationships between noncoding RNAs and immune responses is warranted [PMC7163112].
Literature search
52 open access papers mention hsa-mir-187
(335 sentences)
(335 sentences)
Sequence
9261
reads,
104
reads per million, 66 experiments
ggucgggcucaccaugacacagugugagaccucgGGCUACAACACAGGACCCGGGCgcugcucugaccccUCGUGUCUUGUGUUGCAGCCGGagggacgcagguccgca
.(.((((((.............((((...((((.((((.(((((((((((.((((.((......).).)).)).))))))))))).)))).))))..))))))))))).
.(.((((((.............((((...((((.((((.(((((((((((.((((.((......).).)).)).))))))))))).)))).))))..))))))))))).
Structure
g u caccaugacacag aga g A C - C - ug g cgggcu ugug ccuc GGCU CAACACAGGAC CG GG g c c | |||||| |||| |||| |||| ||||||||||| || || | | c gccugg acgc ggaG CCGA GUUGUGUUCUG GC cc c g u a - ------------- -ag G C U U c a uc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr18: 35904818-35904926 [-]
Disease association
hsa-mir-187 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-187-5p
| Accession | MIMAT0004561 |
| Description | Homo sapiens hsa-miR-187-5p mature miRNA |
| Sequence | 35 - GGCUACAACACAGGACCCGGGC - 56 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-187-3p
| Accession | MIMAT0000262 |
| Description | Homo sapiens hsa-miR-187-3p mature miRNA |
| Sequence | 71 - UCGUGUCUUGUGUUGCAGCCGG - 92 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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