miRBase entry: hsa-mir-203a

Stem-loop hsa-mir-203a

Homo sapiens hsa-mir-203a precursor miRNA
Gene family
MIPF0000108; mir-203

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR203A is a gene that is downregulated in certain cell lines, such as A2780, and its expression is not significantly increased in response to estrogen treatments [PMC7766742]. The hypermethylation of the MIR203A gene has been suggested as a marker for predicting the development of metastases in ovarian cancer [PMC8835734]. Previous studies have shown that MIR203A and the MIR200 family are downregulated in D492M cell lines and their expression is crucial for maintaining the epithelial phenotype [PMC7308478]. The MIR203A locus is located on chromosome 14, specifically at chr14:104097437–104137437 [PMC7766742'>PMC7766742]. In stage IV ovarian cancer patients, alterations in six miRNAs, including MIR203A, have been observed [PMC9599289]. Additionally, it has been demonstrated that MIR203A enhances cellular inflammatory responses and cell damage while reducing aggrecan and Col2A1 levels [PMC10002134]. The expression of miR200s and MIR203A was investigated to determine their dependence on ERα [PMC7766742].

- PMC7766742
- PMC8835734
- PMC7308478
- PMC9599289
- PMC10002134

Literature search
297 open access papers mention hsa-mir-203a
(2724 sentences)


49652 reads, 725 reads per million, 128 experiments

g     gg a u   g         c         U    G    A     - ug 
 uguug  g c cgc cgcuggguc AGUGGUUCU AACA UUCA CAGUU c  u
 |||||  | | ||| ||||||||| ||||||||| |||| |||| ||||| |   
 gcgac  c g gcg gcggcccaG UCACCAGGA UUGU AAGU Guuaa g  a
a     ag g c   g         A         U    A    -     c cg 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].

Genome context
chr14: 104117405-104117514 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-203a
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-203a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-203a-3p

Accession MIMAT0000264
Description Homo sapiens hsa-miR-203a-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-203a-5p

Accession MIMAT0031890
Description Homo sapiens hsa-miR-203a-5p mature miRNA
Evidence not_experimental
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  3. PubMed ID: 17622355
    MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?
    Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A
    PLoS One (2007) 2:e610