Accession
MI0000283
Symbol
HGNC:
MIR203A
Description
Homo sapiens
hsa-mir-203a precursor miRNA mir-203
Gene
family?
family?
RF00696;
mir-203
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR203A is a gene that is downregulated in certain cell lines, such as A2780, and its expression is not significantly increased in response to estrogen treatments [PMC7766742]. The hypermethylation of the MIR203A gene has been suggested as a marker for predicting the development of metastases in ovarian cancer [PMC8835734]. Previous studies have shown that MIR203A and the MIR200 family are downregulated in D492M cell lines and their expression is crucial for maintaining the epithelial phenotype [PMC7308478]. The MIR203A locus is located on chromosome 14, specifically at chr14:104097437–104137437 [PMC7766742'>PMC7766742]. In stage IV ovarian cancer patients, alterations in six miRNAs, including MIR203A, have been observed [PMC9599289]. Additionally, it has been demonstrated that MIR203A enhances cellular inflammatory responses and cell damage while reducing aggrecan and Col2A1 levels [PMC10002134]. The expression of miR200s and MIR203A was investigated to determine their dependence on ERα [PMC7766742]. References: - PMC7766742 - PMC8835734 - PMC7308478 - PMC9599289 - PMC10002134
Literature search
297 open access papers mention hsa-mir-203a
(2724 sentences)
(2724 sentences)
Sequence
49652
reads,
725
reads per million, 128 experiments
guguuggggacucgcgcgcuggguccAGUGGUUCUUAACAGUUCAACAGUUcuguagcgcaauuGUGAAAUGUUUAGGACCACUAGacccggcgggcgcggcgacagcga
.(((((..(.(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).)..))))).
.(((((..(.(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).)..))))).
Structure
g gg a u g c U G A - ug uguug g c cgc cgcuggguc AGUGGUUCU AACA UUCA CAGUU c u ||||| | | ||| ||||||||| ||||||||| |||| |||| ||||| | gcgac c g gcg gcggcccaG UCACCAGGA UUGU AAGU Guuaa g a a ag g c g A U A - c cg
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].
Genome context
chr14: 104117405-104117514 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-203a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-203a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-203a-3p
| Accession | MIMAT0000264 |
| Description | Homo sapiens hsa-miR-203a-3p mature miRNA |
| Sequence | 65 - GUGAAAUGUUUAGGACCACUAG - 86 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-203a-5p
| Accession | MIMAT0031890 |
| Description | Homo sapiens hsa-miR-203a-5p mature miRNA |
| Sequence | 27 - AGUGGUUCUUAACAGUUCAACAGUU - 51 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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