Accession
MI0000284
Symbol
HGNC:
MIR204
Description
Homo sapiens
hsa-mir-204 precursor miRNA mir-204
Gene
family?
family?
RF00646;
mir-204
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR204 is a microRNA that has been studied in various contexts [PMC5627761]. In a study using a PLGA delivery system-functionalized titanium, it was found that the presence of PLGA with MIR204 inhibitor did not affect cell survival and proliferation, as indicated by the similar growth curve observed among different cell populations over a 4-day monitoring period [PMC5627761]. Additionally, histone modifications (HDA3) and miRNAs (miR29, MIR204, miR146a, and miR24) have been implicated in the development of anterior segment diseases such as Primary Open Angle Glaucoma [PMC4588317]. Furthermore, a study investigated the correlation between liver fat accumulation due to IDH2 deficiency and MIR204 in a high-fat diet. The results showed a correlation between liver fat accumulation and MIR204 levels as determined by the Pearson correlation coefficient [PMC9492679]. These findings highlight the potential role of MIR204 in various biological processes and diseases.
Literature search
191 open access papers mention hsa-mir-204
(1578 sentences)
(1578 sentences)
Sequence
23274
reads,
816
reads per million, 110 experiments
ggcuacagucuuucuucaugugacucguggacUUCCCUUUGUCAUCCUAUGCCUgagaauauaugaaggagGCUGGGAAGGCAAAGGGACGUucaauugucaucacuggc
.....((((..........(((((...(((((.((((((((((.(((((.((((...............))))))))).)))))))))).)))))...))))).))))..
.....((((..........(((((...(((((.((((((((((.(((((.((((...............))))))))).)))))))))).)))))...))))).))))..
Structure
ggcua cuuucuucau ucg U A U gagaau
cagu gugac uggac UCCCUUUGUC UCCUA GCCU a
|||| ||||| ||||| |||||||||| ||||| |||| u
guca uacug acuUG AGGGAAACGG AGGGU CGga a
---cg ---------c uua C A - ggaagu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].
Genome context
chr9: 70809975-70810084 [-]
Disease association
hsa-mir-204 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-204-5p
| Accession | MIMAT0000265 |
| Description | Homo sapiens hsa-miR-204-5p mature miRNA |
| Sequence | 33 - UUCCCUUUGUCAUCCUAUGCCU - 54 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-204-3p
| Accession | MIMAT0022693 |
| Description | Homo sapiens hsa-miR-204-3p mature miRNA |
| Sequence | 72 - GCUGGGAAGGCAAAGGGACGU - 92 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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