Stem-loop hsa-mir-214

Accession

MI0000290

Symbol

HGNC: MIR214

Description

Homo sapiens hsa-mir-214 precursor miRNA mir-214

Gene
family

RF00660; mir-214

Literature search

289 open access papers mention hsa-mir-214
(2846 sentences)

Sequence

57984 reads, 306 reads per million, 102 experiments

ggccuggcuggacagaguugucaugugucUGCCUGUCUACACUUGCUGUGCagaacauccgcucaccuguACAGCAGGCACAGACAGGCAGUcacaugacaacccagccu
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).

Structure

ggccu      acaga           u          ACA            aacau 
     ggcugg     guugucaugug cUGCCUGUCU   CUUGCUGUGCag     c
     ||||||     ||||||||||| ||||||||||   ||||||||||||     c
     ccgacc     caacaguacac GACGGACAGA   GGACGACAuguc     g
----u      -----           U          CAC            cacuc 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr1: 172138798-172138907 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-214

Disease association

hsa-mir-214 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-214 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-214 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-214-5p

• Accession: MIMAT0004564
• Description: Homo sapiens hsa-miR-214-5p mature miRNA
• Sequence: 30 - UGCCUGUCUACACUUGCUGUGC - 51
• Evidence: experimental ; cloned [2-3], Northern [3]

Mature hsa-miR-214-3p

• Accession: MIMAT0000271
• Description: Homo sapiens hsa-miR-214-3p mature miRNA
• Sequence: 71 - ACAGCAGGCACAGACAGGCAGU - 92
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 18230126
   New miRNAs cloned from neuroblastoma
   "Afanasyeva EA, Hotz-Wagenblatt A, Glatting KH, Westermann F"
   "BMC Genomics (2008) 9:52