Stem-loop hsa-mir-216a

Accession

MI0000292

Symbol

HGNC: MIR216A

Description

Homo sapiens hsa-mir-216a precursor miRNA mir-216

Gene
family

RF00654; mir-216

Literature search

53 open access papers mention hsa-mir-216a
(299 sentences)

Sequence

100360 reads, 1014 reads per million, 36 experiments

gauggcugugaguuggcuUAAUCUCAGCUGGCAACUGUGAgauguucauacaaucccUCACAGUGGUCUCUGGGAUUAUgcuaaacagagcaauuuccuagcccucacga
((.(((((.((((((((.(((((((((..(((.((((((((.(((....)))....)))))))).))).))))))))).)))))..........))).))))).))....

Structure

----  u     u   ----------     u         CU   A        ---a   u 
    ga ggcug gag          uuggc UAAUCUCAG  GGC ACUGUGAg    ugu c
    || ||||| |||          ||||| |||||||||  ||| ||||||||    |||  
    cu ccgau cuu          aaucg AUUAGGGUC  CUG UGACACUc    aca a
agca  c     c   uaacgagaca     U         -U   G        ccua   u 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr2: 55988950-55989059 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-216a

Disease association

hsa-mir-216a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-216a-5p

• Accession: MIMAT0000273
• Description: Homo sapiens hsa-miR-216a-5p mature miRNA
• Sequence: 19 - UAAUCUCAGCUGGCAACUGUGA - 40
• Evidence: experimental ; cloned [2], SOLiD [3]

Mature hsa-miR-216a-3p

• Accession: MIMAT0022844
• Description: Homo sapiens hsa-miR-216a-3p mature miRNA
• Sequence: 58 - UCACAGUGGUCUCUGGGAUUAU - 79
• Evidence: experimental ; SOLiD [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 22282338
   Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
   "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
   "RNA (2012) 18:472-484