miRBase entry: hsa-mir-216a

Stem-loop hsa-mir-216a

Homo sapiens hsa-mir-216a precursor miRNA
Gene family
MIPF0000054; mir-216

Caution, this is an AI generated summary based on literature. This may have errors. ?

Hsa-mir-216a is highly enriched in KLEC derived exosomes [PMC5570218]. It has been found to be closely related to target DEmRNAs, along with other microRNAs such as hsa-mir-217, hsa-mir-133b, hsa-mir-133a, hsa-mir-145, hsa-mir-211, and hsa-mir-1297 [PMC5565391]. In a study on pancreatic adenocarcinoma, significant differences in expression profiles of hsa-mir-216a were observed between tumor and normal groups [PMC9669652]. The function of hsa-mir-216a may be modulated by microRNA interference, as predicted by TargetScan [PMC5062913]. In another study on papillary renal cell carcinoma (PRCC), hsa-miR-211 and five DEmiRNAs (hsa-miR-145, hsa-miR-184, hsa-mir-214, hsa-mir-216a, hsa-miR-217) were significantly associated with overall survival [PMC6522832]. Additionally, the upregulation of hsa-miR-135b and hsa-mir-216a expression was positively correlated with overall survival in PRCC patients [PMC7499949]. These findings highlight the potential significance of hsa-mir-216a in various cancer types.

Literature search
53 open access papers mention hsa-mir-216a
(299 sentences)


100368 reads, 2416 reads per million, 36 experiments

----  u     u   ----------     u         CU   A        ---a   u 
    ga ggcug gag          uuggc UAAUCUCAG  GGC ACUGUGAg    ugu c
    || ||||| |||          ||||| |||||||||  ||| ||||||||    |||  
    cu ccgau cuu          aaucg AUUAGGGUC  CUG UGACACUc    aca a
agca  c     c   uaacgagaca     U         -U   G        ccua   u 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr2: 55988950-55989059 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-216a
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-216a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-216a-5p

Accession MIMAT0000273
Description Homo sapiens hsa-miR-216a-5p mature miRNA
Evidence experimental
cloned [2], SOLiD [3]
Database links
Predicted targets

Mature hsa-miR-216a-3p

Accession MIMAT0022844
Description Homo sapiens hsa-miR-216a-3p mature miRNA
Evidence experimental
SOLiD [3]


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  3. PubMed ID: 22282338
    Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
    "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
    "RNA (2012) 18:472-484