miRBase entry: hsa-mir-223

Stem-loop hsa-mir-223

Homo sapiens hsa-mir-223 precursor miRNA
Gene family
MIPF0000067; mir-223

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR223 is a microRNA that has been found to play a role in various biological processes. In MIR223 deficient mice, an increase in granulocyte numbers and abnormal phenotype has been observed, leading to the development of inflammatory lung pathology [PMC7871001]. Microarray analyses have shown that MIR223 is enriched in microglia [PMC6351131]. Another short RNA, MIR223 derived from thrombin activated PL-EVs, has been found to regulate the endothelial expression of FBXW7 and EFNA1 mRNA targets [PMC8468534]. While upregulation of MIR223 in peripheral plasma has been reported, its expression was significantly decreased in SLE patients with active nephritis [PMC7871001]. CircMTO1 was found to act as a sponge for both miR9 and MIR223 [PMC7093694]. In hepatocellular carcinoma (HCC), MIR223 levels are depleted in tissues but its concentration rises in serum, suggesting its potential as a serum biomarker for HCC [PMC4581219]. Mutated rs3750996 was reported to affect the binding affinity of MIR223 but further investigations are needed to determine its influence on STIM1 gene expression [PMC7767290]. Deregulated miRNAs such as miR199-214, miR371-373, and MIR223 have been implicated in various cellular processes including tumor metabolism, p53 pathway regulation, cell cycle regulation, Wnt/β-catenin signaling, apoptosis and cell growth through FBXW7 [PMC9495386]. In the miRNA-mediated synaptic plasticity regulating pathway, MIR501 targets GluR1 while both MIR223 and miR134 target GluR2 and NR2B respectively [PMC4783348].

Literature search
400 open access papers mention hsa-mir-223
(2690 sentences)


106277 reads, 1820 reads per million, 97 experiments

c    ccuccu   -     a    cC U              GAGUUg       cau 
 cugg      gca gugcc cgcu  G GUAUUUGACAAGCU      gacacuc   g
 ||||      ||| ||||| ||||  | ||||||||||||||      |||||||   u
 gacc      cgu cacgg guga  C CAUAAACUGUUUGA      CUGUgag   g
-    ---auu   a     c    AC C              ------       aug 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chrX: 66018870-66018979 [+]

Disease association
hsa-mir-223 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-223-5p

Accession MIMAT0004570
Description Homo sapiens hsa-miR-223-5p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-223-3p

Accession MIMAT0000280
Description Homo sapiens hsa-miR-223-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540