Accession
MI0000301
Symbol
HGNC:
MIR224
Description
Homo sapiens
hsa-mir-224 precursor miRNA mir-224
Gene
family?
family?
RF00680;
mir-224
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR224 is a microRNA that has been implicated in various biological processes and diseases. It has been shown to be up-regulated in siAQP4 treated animals, leading to a reduction in Cx43 expression [PMC5843607]. Estradiol (E2) is known to play a crucial role in the regulation of MIR224, and it has been identified as a key regulator of MIR224 in both esophageal adenocarcinoma (EA) and esophageal squamous cell carcinoma (ESCC) [PMC6609598]. In addition, MIR224 has been identified as a potential biomarker for EA [PMC6609598]. Aberrant expression of miRNAs, including MIR224, has also been observed in autoimmune diseases such as lupus erythematosus [PMC5351619]. MIR224 is one of the miRNAs involved in the progression of pancreatic adenocarcinoma (PAAD) [PMC6005310]. It also plays a critical role in chemoresistance in ovarian cancer cells by regulating the PRKCD pathway [PMC8071157]. Furthermore, MIR224 targets glycine methyltransferases and is involved in epithelial-mesenchymal transition (EMT) regulation in colorectal cancer [PMC9775527] [PMC5240405]. It has also been implicated as a prognostic candidate for colorectal cancer [PMC5935085]. Additionally, MIR224 is overexpressed in WNT medulloblastomas and promotes migration of hepatocellular carcinoma (HCC) and colorectal cancer (CRC) by binding to Smad4 and HOXD10 proteins [PMC4333163] [PMC5226496]. Furthermore, it regulates NCR1 expression levels and plays a role in post-stroke angiogenesis processes along with other miRNAs such as miR225, miR335, and miR139-5p [PMC9166526] [PMC6732937].
Literature search
123 open access papers mention hsa-mir-224
(843 sentences)
(843 sentences)
Sequence
19600
reads,
734
reads per million, 116 experiments
gggcuuUCAAGUCACUAGUGGUUCCGUUUAGuagaugauugugcauuguuucAAAAUGGUGCCCUAGUGACUACAaagccc
(((((((..(((((((((.(((.((((((.(.(((((((.....)))))))).)))))).))))))))))))..)))))))
(((((((..(((((((((.(((.((((((.(.(((((((.....)))))))).)))))).))))))))))))..)))))))
Structure
CA U U A u u
gggcuuU AGUCACUAG GGU CCGUUU G agaugau g
||||||| ||||||||| ||| |||||| | ||||||| u
cccgaaA UCAGUGAUC CCG GGUAAA c uuuguua g
CA - U A - c
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 151958578-151958658 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-224
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-224 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-224 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-224 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-224-5p
| Accession | MIMAT0000281 |
| Description | Homo sapiens hsa-miR-224-5p mature miRNA |
| Sequence | 7 - UCAAGUCACUAGUGGUUCCGUUUAG - 31 |
| Evidence |
experimental
cloned [1-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-224-3p
| Accession | MIMAT0009198 |
| Description | Homo sapiens hsa-miR-224-3p mature miRNA |
| Sequence | 53 - AAAAUGGUGCCCUAGUGACUACA - 75 |
| Evidence |
experimental
qRT-PCR [5], 454 [6] |
| Database links |
|
| Predicted targets |
|
References
|
