Stem-loop hsa-mir-224

Accession

MI0000301

Symbol

HGNC: MIR224

Description

Homo sapiens hsa-mir-224 precursor miRNA mir-224

Gene
family

RF00680; mir-224

Literature search

123 open access papers mention hsa-mir-224
(843 sentences)

Sequence

19444 reads, 167 reads per million, 116 experiments

gggcuuUCAAGUCACUAGUGGUUCCGUUUAGuagaugauugugcauuguuucAAAAUGGUGCCCUAGUGACUACAaagccc
(((((((..(((((((((.(((.((((((.(.(((((((.....)))))))).)))))).))))))))))))..)))))))

Structure

       CA         U   U      A u       u 
gggcuuU  AGUCACUAG GGU CCGUUU G agaugau g
|||||||  ||||||||| ||| |||||| | ||||||| u
cccgaaA  UCAGUGAUC CCG GGUAAA c uuuguua g
       CA         -   U      A -       c 

Annotation confidence High

Genome context

chrX: 151958578-151958658 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-224

Disease association

hsa-mir-224 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-224 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-224 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-224-5p

• Accession: MIMAT0000281
• Description: Homo sapiens hsa-miR-224-5p mature miRNA
• Sequence: 7 - UCAAGUCACUAGUGGUUCCGUUUAG - 31
• Evidence: experimental ; cloned [1-4]

Mature hsa-miR-224-3p

• Accession: MIMAT0009198
• Description: Homo sapiens hsa-miR-224-3p mature miRNA
• Sequence: 53 - AAAAUGGUGCCCUAGUGACUACA - 75
• Evidence: experimental ; qRT-PCR [5], 454 [6]

References

1. PubMed ID: 12554860
   Numerous microRNPs in neuronal cells containing novel microRNAs
   "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
   "RNA (2003) 9:180-186


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 19015728
   MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cells
   Tzur G, Levy A, Meiri E, Barad O, Spector Y, Bentwich Z, Mizrahi L, Katzenellenbogen M, Ben-Shushan E, Reubinoff BE, Galun E
   PLoS One (2008) 3:e3726


5. PubMed ID: 19144710
   Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
   "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
   "J Virol (2009) 83:3333-3341


6. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706