Accession
MI0000312
Description
Caenorhabditis elegans
cel-mir-237 precursor miRNA mir-237
Gene
family?
family?
RF03920;
mir-237
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Cel-mir-237, a microRNA identified in Caenorhabditis elegans, has been implicated in the modulation of radiation sensitivity [PMC4247386]. Research indicates that a deficiency in cel-mir-237 is associated with radioresistance, while its overexpression leads to increased radiosensitivity [PMC5173455]. The microRNA appears to regulate the expression of jun-1, a gene that is crucial for cellular survival following γ-irradiation [PMC5173455]. An inverse relationship between the levels of cel-mir-237 and jun-1 has been observed post γ-irradiation, with jun-1 levels rising following a decrease in cel-mir-237 [PMC5173455]. This suggests that cel-mir-237 downregulates jun-1 and that this interaction is important for the cellular response to DNA damage caused by γ-rays [PMC5173455'>PMC5173455]. The human homolog of cel-mir-237, hsa-miR-125b, has also been shown to induce radiosensitivity by targeting JUN proteins in human breast cancer cell lines [PMC5173455]. These findings underscore the potential role of cel-mir-237 and its homologs in influencing radiation response through genetic pathways involving jun family proteins [PMC5173455].
Literature search
5 open access papers mention cel-mir-237
(11 sentences)
(11 sentences)
Sequence
13091
reads,
394
reads per million, 11 experiments
uucuacauugcguggUCCCUGAGAAUUCUCGAACAGCUucaaaguguucaagCUGUCGAGUUUUGUCAAGGACCaaacaauagaagaucacuugggaac
(((((..(((..((((((.(((.((..(((((.((((((.((....)).)))))))))))..)).))).))))))..))))))))..............
(((((..(((..((((((.(((.((..(((((.((((((.((....)).)))))))))))..)).))).))))))..))))))))..............
Structure
-------------- ca cg C G UU A c a
uucua uug uggUCC UGA AA CUCGA CAGCUu aa g
||||| ||| |||||| ||| || ||||| |||||| ||
aagau aac aCCAGG ACU UU GAGCU GUCgaa uu u
caaggguucacuag -- aa A G UU - c g
Annotation confidence
High
Do you think this miRNA is real?
Comments
The sequence is reported to be related to lin-4 [2]. The extents of the dominant mature miRNA species are adjusted here in accordance with a large scale cloning and sequencing study [3].
Genome context
chrX: 8154084-8154182 [+]
Database links
Mature cel-miR-237-5p
| Accession | MIMAT0000292 |
| Description | Caenorhabditis elegans cel-miR-237-5p mature miRNA |
| Sequence | 16 - UCCCUGAGAAUUCUCGAACAGCU - 38 |
| Evidence |
experimental
cloned [1-3], Northern [1], Illumina [4,6], CLIPseq [5] |
| Database links |
|
| Predicted targets |
|
Mature cel-miR-237-3p
| Accession | MIMAT0020333 |
| Description | Caenorhabditis elegans cel-miR-237-3p mature miRNA |
| Sequence | 53 - CUGUCGAGUUUUGUCAAGGACC - 74 |
| Evidence |
experimental
Illumina [6] |
| Database links |
|
References
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