Accession
MI0000312
Description
Caenorhabditis elegans
cel-mir-237 precursor miRNA mir-237
Gene
family?
family?
RF03920;
mir-237
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Cel-mir-237 is a microRNA (miRNA) that has been identified as a potential predictor of radioresistance [PMC4247386]. It has been found that loss of cel-mir-237 is associated with radioresistance [PMC5173455]. Additionally, there is a temporal correlation between cel-mir-237 and jun-1 expression post-γ-irradiation [PMC5173455]. Experimental studies have shown that cel-mir-237 can alter radiation sensitivity and downregulate jun-1 levels, which is important for cellular survival post-γ-irradiation [PMC5173455]. The expression profile of cel-mir-237 is inversely correlated with jun-1 expression [PMC5173455'>PMC5173455'>PMC5173455'>PMC5173455]. Both cel-mir-237 and hsa-miR125b have been found to induce radiation sensitivity by targeting and downregulating JUN [PMC5173455]. It has been predicted that jun1 is a target of cel-mir-237 based on sequence and conservation analysis [PMC5173455]. The loss of cel-mir-237 protects cells from γ-radiation, while overexpression of cel-miR 237 promotes radiosensitivity in C. elegans nematodes [PMC5173455]. The levels of cel-miR 237 significantly decrease in wild-type N2 animals after γ-radiation treatment, suggesting an active downregulation mechanism to promote survival during and after γ-radiation exposure [PMC5173455].
Literature search
5 open access papers mention cel-mir-237
(11 sentences)
(11 sentences)
Sequence
13091
reads,
394
reads per million, 11 experiments
uucuacauugcguggUCCCUGAGAAUUCUCGAACAGCUucaaaguguucaagCUGUCGAGUUUUGUCAAGGACCaaacaauagaagaucacuugggaac
(((((..(((..((((((.(((.((..(((((.((((((.((....)).)))))))))))..)).))).))))))..))))))))..............
(((((..(((..((((((.(((.((..(((((.((((((.((....)).)))))))))))..)).))).))))))..))))))))..............
Structure
-------------- ca cg C G UU A c a
uucua uug uggUCC UGA AA CUCGA CAGCUu aa g
||||| ||| |||||| ||| || ||||| |||||| ||
aagau aac aCCAGG ACU UU GAGCU GUCgaa uu u
caaggguucacuag -- aa A G UU - c g
Annotation confidence
High
Do you think this miRNA is real?
Comments
The sequence is reported to be related to lin-4 [2]. The extents of the dominant mature miRNA species are adjusted here in accordance with a large scale cloning and sequencing study [3].
Genome context
chrX: 8154084-8154182 [+]
Database links
Mature cel-miR-237-5p
| Accession | MIMAT0000292 |
| Description | Caenorhabditis elegans cel-miR-237-5p mature miRNA |
| Sequence | 16 - UCCCUGAGAAUUCUCGAACAGCU - 38 |
| Evidence |
experimental
cloned [1-3], Northern [1], Illumina [4,6], CLIPseq [5] |
| Database links |
|
| Predicted targets |
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Mature cel-miR-237-3p
| Accession | MIMAT0020333 |
| Description | Caenorhabditis elegans cel-miR-237-3p mature miRNA |
| Sequence | 53 - CUGUCGAGUUUUGUCAAGGACC - 74 |
| Evidence |
experimental
Illumina [6] |
| Database links |
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References
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