Stem-loop cel-mir-252

Accession

MI0000328

Description

Caenorhabditis elegans cel-mir-252 precursor miRNA mir-252

Gene
family

RF00838; mir-252

Literature search

2 open access papers mention cel-mir-252
(47 sentences)

Sequence

72170 reads, 448 reads per million, 16 experiments

uccaggggucucuuucaguuAUAAGUAGUAGUGCCGCAGGUAAccgccagucuaaaaggCUUACCUACUGCCUUCUGCuuaaaauugaaauauugaug
.......(((..((((((((.(((((((.((.((.(.((((((..(((.........))))))))).).)))).))))))).))))))))....))).

Structure

uccaggg   --uc        A       U  U  C C      cc   agu 
       guc    uuucaguu UAAGUAG AG GC G AGGUAA  gcc   c
       |||    |||||||| ||||||| || || | ||||||  |||   u
       uag    aaaguuaa auuCGUC UC CG C UCCAUU  Cgg   a
------g   uuau        a       U  -  U A      --   aaa 

Annotation confidence High

Comments

The extents of the dominant mature miRNA species are adjusted here in accordance with a large scale cloning and sequencing study [2].

Genome context

chrII: 11446863-11446960 [-]

Mature cel-miR-252-5p

• Accession: MIMAT0000308
• Description: Caenorhabditis elegans cel-miR-252-5p mature miRNA
• Sequence: 21 - AUAAGUAGUAGUGCCGCAGGUAA - 43
• Evidence: experimental ; Northern [1-2], PCR [1], Illumina [3,5], CLIPseq [4]

Mature cel-miR-252-3p

• Accession: MIMAT0020340
• Description: Caenorhabditis elegans cel-miR-252-3p mature miRNA
• Sequence: 60 - CUUACCUACUGCCUUCUGC - 78
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 12672692
   The microRNAs of Caenorhabditis elegans
   "Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP"
   "Genes Dev (2003) 17:991-1008


2. PubMed ID: 17174894
   Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
   "Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H, Bartel DP"
   "Cell (2006) 127:1193-1207


3. PubMed ID: 19460142
   Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development
   Kato M, de Lencastre A, Pincus Z, Slack FJ
   Genome Biol (2009) 10:R54


4. PubMed ID: 20062054
   Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
   "Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli AE, Yeo GW"
   "Nat Struct Mol Biol (2010) 17:173-179


5. PubMed ID: 21307183
   Improved annotation of C. elegans microRNAs by deep sequencing reveals structures associated with processing by Drosha and Dicer
   "Warf MB, Johnson WE, Bass BL"
   "RNA (2011) 17:563-577