Accession
MI0000368
Description
Drosophila melanogaster
dme-mir-283 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Dme-mir-283 is a highly upregulated miRNA in fly cells following alphavirus infection, regardless of the presence of Wolbachia [PMC8402854]. In silico miRNA prediction suggests that dme-mir-283 has the potential to target the 3' untranslated region (3'UTR) of the DmDNMT2 gene [PMC8402854]. It is assumed that dme-mir-283 downregulates DmDNMT2 expression, which is consistent with the expression pattern of this miRNA and its target in adult flies [PMC8402854]. The expression profile of dme-mir-283 does not correlate with dme-mir-304 and dme-mir-12, but there is a correlation between dme-mir-304 and dme-mir-12 [PMC3150300]. Additionally, there is no correlation between dme-mir-283* and either dme-mir-283 itself or other miRNAs in its cluster [PMC3150300]. The expression profiles of several other miRNAs, including dme-mir-100, dme-mir-992, and dme-mir-306, also have low correlation coefficients with profiles of their corresponding miRNAs* [PMC3150300]. Furthermore, the expression profiles of several other miRNAs such as dme-miR305 and 100 have weak correlations with at least one miRNA from their respective clusters [PMC3150300]. References: [PMC8402854] - Schnettler E., Donald C.L., Human S., Watson M., Siu R.W.C., McFarlane M. et al. (2021) Wolbachia restricts alphavirus replication in mosquito cells via competition for methyl donors that fuel virus methyltransferases. PLoS Pathog 17(1): e1008402. [PMC3150300] - Wen J., Mohammed J., Bortolamiol-Becet D., Tsai H., Robine N., Westholm J.O. et al. (2014) Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Res 24(7): 1236-1250.
Literature search
9 open access papers mention dme-mir-283
(17 sentences)
(17 sentences)
Sequence
395575
reads,
2309
reads per million, 49 experiments
cucacacgauucucaaagguAAAUAUCAGCUGGUAAUUCUGGgagcuaagccuaaauaugaaacacuCGGAAUUUCAGUUGGUAUCGAcuuuuuugaauu
.......(((((..((((((..(((((((((((.(((((((((......................))))))))))))))))))))..))))))..)))))
.......(((((..((((((..(((((((((((.(((((((((......................))))))))))))))))))))..))))))..)))))
Structure
cucacac uc AA U agcuaagccu
gauuc aaaggu AUAUCAGCUGG AAUUCUGGg a
||||| |||||| ||||||||||| |||||||||
uuaag uuuucA UAUGGUUGACU UUAAGGCuc a
------- uu GC - acaaaguaua
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 15507956-15508055 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-283
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature dme-miR-283-5p
| Accession | MIMAT0000347 |
| Description | Drosophila melanogaster dme-miR-283-5p mature miRNA |
| Sequence | 21 - AAAUAUCAGCUGGUAAUUCUGG - 42 |
| Evidence |
experimental
Northern [1-2], 454 [3-4], Illumina [4] |
| Database links |
|
| Predicted targets |
|
Mature dme-miR-283-3p
| Accession | MIMAT0020810 |
| Description | Drosophila melanogaster dme-miR-283-3p mature miRNA |
| Sequence | 68 - CGGAAUUUCAGUUGGUAUCGA - 88 |
| Evidence | not_experimental |
| Database links |
|
References
|
