miRBase entry: dme-mir-283

Stem-loop dme-mir-283

Drosophila melanogaster dme-mir-283 precursor miRNA
Gene family
MIPF0000054; mir-216

Caution, this is an AI generated summary based on literature. This may have errors. ?

Dme-mir-283 is a highly upregulated miRNA in fly cells following alphavirus infection, regardless of the presence of Wolbachia [PMC8402854]. In silico miRNA prediction suggests that dme-mir-283 has the potential to target the 3' untranslated region (3'UTR) of the DmDNMT2 gene [PMC8402854]. It is assumed that dme-mir-283 downregulates DmDNMT2 expression, which is consistent with the expression pattern of this miRNA and its target in adult flies [PMC8402854]. The expression profile of dme-mir-283 does not correlate with dme-mir-304 and dme-mir-12, but there is a correlation between dme-mir-304 and dme-mir-12 [PMC3150300]. Additionally, there is no correlation between dme-mir-283* and either dme-mir-283 itself or other miRNAs in its cluster [PMC3150300]. The expression profiles of several other miRNAs, including dme-mir-100, dme-mir-992, and dme-mir-306, also have low correlation coefficients with profiles of their corresponding miRNAs* [PMC3150300]. Furthermore, the expression profiles of several other miRNAs such as dme-miR305 and 100 have weak correlations with at least one miRNA from their respective clusters [PMC3150300].

[PMC8402854] - Schnettler E., Donald C.L., Human S., Watson M., Siu R.W.C., McFarlane M. et al. (2021) Wolbachia restricts alphavirus replication in mosquito cells via competition for methyl donors that fuel virus methyltransferases. PLoS Pathog 17(1): e1008402.
[PMC3150300] - Wen J., Mohammed J., Bortolamiol-Becet D., Tsai H., Robine N., Westholm J.O. et al. (2014) Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Res 24(7): 1236-1250.

Literature search
9 open access papers mention dme-mir-283
(17 sentences)


395575 reads, 2309 reads per million, 49 experiments

cucacac     uc      AA           U         agcuaagccu 
       gauuc  aaaggu  AUAUCAGCUGG AAUUCUGGg          a
       |||||  ||||||  ||||||||||| |||||||||           
       uuaag  uuuucA  UAUGGUUGACU UUAAGGCuc          a
-------     uu      GC           -         acaaaguaua 

Annotation confidence High
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Genome context
chrX: 15507956-15508055 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-283
Name Accession Chromosome Start End Strand Confidence

Database links

Mature dme-miR-283-5p

Accession MIMAT0000347
Description Drosophila melanogaster dme-miR-283-5p mature miRNA
Evidence experimental
Northern [1-2], 454 [3-4], Illumina [4]
Database links
Predicted targets

Mature dme-miR-283-3p

Accession MIMAT0020810
Description Drosophila melanogaster dme-miR-283-3p mature miRNA
Evidence not_experimental
Database links


  1. PubMed ID: 12919683
    The small RNA profile during Drosophila melanogaster development
    "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
    "Dev Cell (2003) 5:337-350

  2. PubMed ID: 17989254
    Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
    "Genome Res (2007) 17:1850-1864

  3. PubMed ID: 17989255
    Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
    "Genome Res (2007) 17:1865-1879

  4. PubMed ID: 12844358
    Computational identification of Drosophila microRNA genes
    "Lai EC, Tomancak P, Williams RW, Rubin GM"
    "Genome Biol (2003) 4:R42