miRBase entry: dme-mir-34

Stem-loop dme-mir-34

Drosophila melanogaster dme-mir-34 precursor miRNA
Gene family
MIPF0000039; mir-34

Literature search
35 open access papers mention dme-mir-34
(375 sentences)


3285512 reads, 32763 reads per million, 49 experiments

aauug   a  -   uu        U  U   C        --ua c    ua 
     gcu ug cgc  UGGCAGUG GG UAG UGGUUGUG    g caau  u
     ||| || |||  |||||||| || ||| ||||||||    | ||||  u
     cga ac gcg  GCCGUCAC UC AUC ACCGACac    c guug  g
-----   -  a   CC        U  U   -        uuaa a    cc 

Annotation confidence High
Do you think this miRNA is real?
This sequence is computationally predicted based on conservation in D. pseudoobscura and C. elegans. The precise 5' or 3' ends are unknown. Expression in D. melanogaster was confirmed by Northern blot analysis [1]. Aravin et al. later identify the 5' and 3' ends by cloning [3].

Genome context
chr3R: 10100936-10101034 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-34
Name Accession Chromosome Start End Strand Confidence

Database links

Mature dme-miR-34-5p

Accession MIMAT0000350
Description Drosophila melanogaster dme-miR-34-5p mature miRNA
Evidence experimental
Northern [1], cloned [3], 454 [4-5], Illumina [5]
Database links
Predicted targets

Mature dme-miR-34-3p

Accession MIMAT0020812
Description Drosophila melanogaster dme-miR-34-3p mature miRNA
Evidence not_experimental
Database links


  1. PubMed ID: 12812784
    Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    "Sempere LF, Sokol NS, Dubrovsky EB, Berger EM, Ambros V"
    "Dev Biol (2003) 259:9-18

  2. PubMed ID: 12919683
    The small RNA profile during Drosophila melanogaster development
    "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
    "Dev Cell (2003) 5:337-350

  3. PubMed ID: 17989254
    Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
    "Genome Res (2007) 17:1850-1864

  4. PubMed ID: 17989255
    Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
    "Genome Res (2007) 17:1865-1879

  5. PubMed ID: 12844358
    Computational identification of Drosophila microRNA genes
    "Lai EC, Tomancak P, Williams RW, Rubin GM"
    "Genome Biol (2003) 4:R42