miRBase entry: dme-mir-100

Stem-loop dme-mir-100

Drosophila melanogaster dme-mir-100 precursor miRNA
Gene family
MIPF0000033; mir-10

Caution, this is an AI generated summary based on literature. This may have errors. ?

Dme-mir-100 is a derived mature microRNA that is assigned the name dme-mir-100 for the guide strand and dme-mir-100* for the passenger strand [PMC4451068]. The prefix "dme" in dme-mir-100 designates the organism, Drosophila melanogaster, and is followed by sequentially assigned numbers [PMC4718083]. Dme-mir-100, along with dme-miR-92a and dme-miR-124, was selected based on data generated in a laboratory and their orthology with human miRNAs [PMC5090246]. Drosophila miRNAs, including dme-mir-100, show extensive overall similarity with human miRNAs with 5' mismatches [PMC2486268]. The expression profiles of dme-mir-100 have low correlation coefficients with profiles of its corresponding miRNA* [PMC3150300]. A weak correlation between dme-mir-100 and its passenger strand (dme-mir-100*) suggests possible regulation during its maturation [PMC3150300]. Notably, tissue-specific A-to-I editing of dme-mir-100 has been observed in male heads and a cell line [PMC3150300]. The expression profiles of dme-miR-305, along with other miRNAs including dme-miR-283 and dmiR992, are weakly correlated to at least one miRNA from their clusters [PMC3150300]. Independent regulation of both Drosophila let7 (dmiR let7) and mir 100 has been observed during post-transcriptional regulation [PMC3150300]. Several other miRNAs have also been reported to be involved in metamorphosis development in insects including DmiR125, DmiR34a, and DmiR14 [PMC5689003].

Literature search
18 open access papers mention dme-mir-100
(82 sentences)


10859 reads, 245 reads per million, 46 experiments

-------------------c    a     AA       AU   AA      - u uuu 
                    cauu acaga  CCCGUAA  CCG  CUUGUG c g   u
                    |||| |||||  |||||||  |||  |||||| | |    
                    guaa uguCU  GGGUAUU  GGC  GAACau g c   a
acgguuuuuggucaacaaac    c     GA       AC   CA      u u uau 

Annotation confidence High
Do you think this miRNA is real?
miR-100 was reported independently by three groups using computational prediction [2], Northern blot analysis [1] and cloning [3]. References [1] and [2] confirmed that the strand containing the predicted miR is predominantly expressed [1]. Reference [3] confirmed the ends of the excised miRNA by cloning.

Genome context
chr2L: 18471434-18471533 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-100
Name Accession Chromosome Start End Strand Confidence

Database links

Mature dme-miR-100-5p

Accession MIMAT0000357
Description Drosophila melanogaster dme-miR-100-5p mature miRNA
Evidence experimental
Northern [1,3], 454 [4-5], Illumina [5]
Database links
Predicted targets

Mature dme-miR-100-3p

Accession MIMAT0020818
Description Drosophila melanogaster dme-miR-100-3p mature miRNA
Evidence not_experimental
Database links


  1. PubMed ID: 12812784
    Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    "Sempere LF, Sokol NS, Dubrovsky EB, Berger EM, Ambros V"
    "Dev Biol (2003) 259:9-18

  2. PubMed ID: 12919683
    The small RNA profile during Drosophila melanogaster development
    "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
    "Dev Cell (2003) 5:337-350

  3. PubMed ID: 17989254
    Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
    "Genome Res (2007) 17:1850-1864

  4. PubMed ID: 17989255
    Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
    "Genome Res (2007) 17:1865-1879

  5. PubMed ID: 12844358
    Computational identification of Drosophila microRNA genes
    "Lai EC, Tomancak P, Williams RW, Rubin GM"
    "Genome Biol (2003) 4:R42