Stem-loop mmu-mir-34b

Accession

MI0000404

Symbol

MGI: Mir34b

Description

Mus musculus mmu-mir-34b precursor miRNA mir-34

Gene
family

RF00456; mir-34

Literature search

208 open access papers mention mmu-mir-34b
(1296 sentences)

Sequence

48562 reads, 1516 reads per million, 86 experiments

gugcucgguuuguAGGCAGUGUAAUUAGCUGAUUGUagugcggugcugacAAUCACUAACUCCACUGCCAUCaaaacaaggcac
(((((..((((...(((((((...((((.((((((((((.....))).)))))))))))...)))))))....))))..)))))

Structure

     cg    -guA       UAA    C       -   g 
gugcu  guuu    GGCAGUG   UUAG UGAUUGU agu c
|||||  ||||    |||||||   |||| ||||||| ||| g
cacgg  caaa    CCGUCAC   AAUC ACUAAca ucg g
     aa    aCUA       CUC    -       g   u 

Annotation confidence Medium

Comments

Houbaviy et al. cloned 3 closely related sequences from mouse embryonic stem cells [1], and named them miR-34a, miR-34b and miR-172. These names have been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) and miR-34a (MIR:MI0000584) to clarify homology with human sequences. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr9: 51103562-51103645 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-34b

Mature mmu-miR-34b-5p

• Accession: MIMAT0000382
• Description: Mus musculus mmu-miR-34b-5p mature miRNA
• Sequence: 14 - AGGCAGUGUAAUUAGCUGAUUGU - 36
• Evidence: experimental ; cloned [1-2], Illumina [3-4]

Mature mmu-miR-34b-3p

• Accession: MIMAT0004581
• Description: Mus musculus mmu-miR-34b-3p mature miRNA
• Sequence: 51 - AAUCACUAACUCCACUGCCAUC - 72
• Evidence: experimental ; cloned [2], Illumina [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009