miRBase entry: hsa-mir-15b

Stem-loop hsa-mir-15b

Homo sapiens hsa-mir-15b precursor miRNA
Gene family
MIPF0000006; mir-15

Caution, this is an AI generated summary based on literature. This may have errors. ?

Hsa-mir-15b is a microRNA that has been studied in relation to its expression in CD34+ HSCs [PMC4669904]. One study found that the expression of Sall4, a transcription factor, was inversely correlated with the expression of hsa-mir-15b and hsa-miR-219-5p in CD34+ HSCs [PMC4669904]. Another study evaluated the performance of different miRNAs as potential biomarkers and found that hsa-mir-15b had an area under the ROC curve (AUROC) of 0.726 [PMC9279521]. The AUROC is a measure of how well a biomarker can distinguish between different groups, with values closer to 1 indicating better performance [PMC9279521]. The study also reported AUROC values for other miRNAs, such as hsa-mir-200c (0.784), hsa-mir-141 (0.894), and hsa-mir-16-2 (0.752) [PMC9279521]. These findings suggest that hsa-mir-15b may play a role in regulating gene expression in CD34+ HSCs and could potentially be used as a biomarker for certain conditions or diseases [PMC4669904] [PMC9279521]. However, further research is needed to fully understand its function and potential clinical applications [PMC4669904] [PMC9279521].

Literature search
405 open access papers mention hsa-mir-15b
(1510 sentences)


476877 reads, 5285 reads per million, 129 experiments

u    --g       gua   U       C  C       A   g  ac 
 ugag   ccuuaaa   cug AGCAGCA AU AUGGUUU CAu cu  a
 ||||   |||||||   ||| ||||||| || ||||||| ||| ||  g
 acuu   ggaauuu   gAU UCGUCGU UA UACUAAG gua ga  u
u    aaa       aaa   C       U  U       C   -  ac 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-15b in human [2].

Genome context
chr3: 160404588-160404685 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-15b
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-15b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-15b-5p

Accession MIMAT0000417
Description Homo sapiens hsa-miR-15b-5p mature miRNA
Evidence experimental
cloned [2-5]
Database links
Predicted targets

Mature hsa-miR-15b-3p

Accession MIMAT0004586
Description Homo sapiens hsa-miR-15b-3p mature miRNA
Evidence experimental
cloned [4-5]
Database links
Predicted targets


  1. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739