miRBase entry: hsa-mir-122

Stem-loop hsa-mir-122


Accession
MI0000442
Symbol
HGNC: MIR122
Description
Homo sapiens hsa-mir-122 precursor miRNA mir-122
Gene
family?
RF00684; mir-122

Literature search
562 open access papers mention hsa-mir-122
(3998 sentences)

Sequence

335022 reads, 3777 reads per million, 69 experiments
ccuuagcagagcugUGGAGUGUGACAAUGGUGUUUGugucuaaacuaucaAACGCCAUUAUCACACUAAAUAgcuacugcuaggc
.((((((((((((((..(((((((.(((((((((((............))))))))))).)))))))..)))))).)))))))).

Structure
c        -      GG       C           ugucu 
 cuuagcag agcugU  AGUGUGA AAUGGUGUUUG     a
 |||||||| ||||||  ||||||| |||||||||||      
 ggaucguc ucgAUA  UCACACU UUACCGCAAac     a
c        a      AA       A           uauca 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr18: 58451074-58451158 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-122
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-122 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-122-5p

Accession MIMAT0000421
Description Homo sapiens hsa-miR-122-5p mature miRNA
Sequence 15 - UGGAGUGUGACAAUGGUGUUUG - 36
Evidence experimental
cloned [2-3], Northern [2]
Database links
Predicted targets

Mature hsa-miR-122-3p

Accession MIMAT0004590
Description Homo sapiens hsa-miR-122-3p mature miRNA
Sequence 51 - AACGCCAUUAUCACACUAAAUA - 72
Evidence experimental
cloned [3]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739