Accession
MI0000442
Symbol
HGNC:
MIR122
Description
Homo sapiens
hsa-mir-122 precursor miRNA mir-122
Gene
family?
family?
RF00684;
mir-122
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR122, a liver-specific microRNA, plays a crucial role in various hepatic processes, including lipid metabolism and gluconeogenesis, as mediated through HNF-4α [PMC4806913]. It has been implicated in the regulation of c-Met ecto-domain shedding through ADAM10 processing [PMC7352235]'>PMC7352235], and its reduced function is associated with promoter methylation and decreased SOCS3 expression [PMC3434395]. Interestingly, MIR122 is not essential for HAV-RNA replication [PMC7165973], but its levels can influence HCV replication as demonstrated by the inhibitory effect of apigenin on this process [PMC5812025]. The microRNA has been utilized in therapeutic strategies to reduce virus replication by incorporating its target sequence into the 3'UTR of viral genes for liver-specific inhibition [PMC7281331]. MIR122 also shows potential as a biomarker for early detection and monitoring of NAFLD alongside other miRNAs [PMC9738374]. Its expression levels are crucial in cancer management; reduced MIR122 expression can be targeted with arginine deprivation or sorafenib to manage certain HCCs [PMC4480756], while its absence or downregulation is associated with hepatosteatosis, hepatitis, and tumor development resembling HCC in mice and reduced levels in human HCC cell lines [PMC6177563; PMC6504855].. Furthermore, MIR122 has been identified as a potential onco-suppressor molecule beyond hepatic cancer, including non-small cell lung cancer [PMC7352235].
Literature search
562 open access papers mention hsa-mir-122
(3998 sentences)
(3998 sentences)
Sequence
335022
reads,
3777
reads per million, 69 experiments
ccuuagcagagcugUGGAGUGUGACAAUGGUGUUUGugucuaaacuaucaAACGCCAUUAUCACACUAAAUAgcuacugcuaggc
.((((((((((((((..(((((((.(((((((((((............))))))))))).)))))))..)))))).)))))))).
.((((((((((((((..(((((((.(((((((((((............))))))))))).)))))))..)))))).)))))))).
Structure
c - GG C ugucu cuuagcag agcugU AGUGUGA AAUGGUGUUUG a |||||||| |||||| ||||||| ||||||||||| ggaucguc ucgAUA UCACACU UUACCGCAAac a c a AA A uauca
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr18: 58451074-58451158 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-122
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-122 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-122-5p
| Accession | MIMAT0000421 |
| Description | Homo sapiens hsa-miR-122-5p mature miRNA |
| Sequence | 15 - UGGAGUGUGACAAUGGUGUUUG - 36 |
| Evidence |
experimental
cloned [2-3], Northern [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-122-3p
| Accession | MIMAT0004590 |
| Description | Homo sapiens hsa-miR-122-3p mature miRNA |
| Sequence | 51 - AACGCCAUUAUCACACUAAAUA - 72 |
| Evidence |
experimental
cloned [3] |
References
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