Accession
MI0000455
Symbol
HGNC:
MIR138-2
Description
Homo sapiens
hsa-mir-138-2 precursor miRNA mir-138
Gene
family?
family?
RF00671;
mir-138
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR138-2 is a mouse microRNA that is post-transcriptionally regulated and its expression is dependent on the presence or absence of a certain inhibitor of Dicer in tissues like kidney and liver [PMC2647296]. H19, another microRNA, can sequester hsa-miR-107, leading to the release of NF1 expression in NSCLC tumor tissues [PMC7279016]. Despite having proximal NKX2-5 binding sites, MIR138-2 was not dysregulated [PMC6828809]. In a meta-analysis study, MIR138-2 was found to be significantly associated with CAG length in the meta-analysis of Series 1 6 and 10-month data [PMC5764268]. MIR138-1 and MIR138-2 are two distinct genes that encode miR-138 [PMC7376782]. The duplication of the MIR138-2 locus has been identified as one of the copy number variations (CNVs) associated with miR-138 expression [PMC8005705]. miR-137 is expressed from a single locus on Chromosome 3, while miR-138 has two distinct genomic loci (Mir138-1 and MIR138-2) on Chromosomes 8 and 9 in mice [PMC6836737]. In addition to its role in gene regulation during early embryonic development, miR290 has also been associated with maintaining pluripotent cell state [PMC4430308]. Furthermore, MIR138-2 has been implicated in cancer processes such as tumor suppression [PMC9763387].
Literature search
226 open access papers mention hsa-mir-138-2
(1607 sentences)
(1607 sentences)
Sequence
73255
reads,
512
reads per million, 82 experiments
cguugcugcAGCUGGUGUUGUGAAUCAGGCCGacgagcagcgcauccucuuacccgGCUAUUUCACGACACCAGGGUUgcauca
.(.(((.((..(((((((((((((...(((((..(((.((......)))))...)))))..))))))))))))).)).))).).
.(.(((.((..(((((((((((((...(((((..(((.((......)))))...)))))..))))))))))))).)).))).).
Structure
c u u AG UCA -ac c cg g ugc gc CUGGUGUUGUGAA GGCCG gag ag c | ||| || ||||||||||||| ||||| ||| || c acg UG GACCACAGCACUU UCGgc uuc uc a a u U -G -UA cca - cu
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr16: 56858518-56858601 [+]
Disease association
hsa-mir-138-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-138-5p
| Accession | MIMAT0000430 |
| Description | Homo sapiens hsa-miR-138-5p mature miRNA |
| Sequence | 10 - AGCUGGUGUUGUGAAUCAGGCCG - 32 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-138-2-3p
| Accession | MIMAT0004596 |
| Description | Homo sapiens hsa-miR-138-2-3p mature miRNA |
| Sequence | 57 - GCUAUUUCACGACACCAGGGUU - 78 |
| Evidence |
experimental
cloned [2] |
References
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