miRBase entry: hsa-mir-138-2

Stem-loop hsa-mir-138-2

HGNC: MIR138-2
Homo sapiens hsa-mir-138-2 precursor miRNA
Gene family
MIPF0000075; mir-138

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR138-2 is a mouse microRNA that is post-transcriptionally regulated and its expression is dependent on the presence or absence of a certain inhibitor of Dicer in tissues like kidney and liver [PMC2647296]. H19, another microRNA, can sequester hsa-miR-107, leading to the release of NF1 expression in NSCLC tumor tissues [PMC7279016]. Despite having proximal NKX2-5 binding sites, MIR138-2 was not dysregulated [PMC6828809]. In a meta-analysis study, MIR138-2 was found to be significantly associated with CAG length in the meta-analysis of Series 1 6 and 10-month data [PMC5764268]. MIR138-1 and MIR138-2 are two distinct genes that encode miR-138 [PMC7376782]. The duplication of the MIR138-2 locus has been identified as one of the copy number variations (CNVs) associated with miR-138 expression [PMC8005705]. miR-137 is expressed from a single locus on Chromosome 3, while miR-138 has two distinct genomic loci (Mir138-1 and MIR138-2) on Chromosomes 8 and 9 in mice [PMC6836737]. In addition to its role in gene regulation during early embryonic development, miR290 has also been associated with maintaining pluripotent cell state [PMC4430308]. Furthermore, MIR138-2 has been implicated in cancer processes such as tumor suppression [PMC9763387].

Literature search
226 open access papers mention hsa-mir-138-2
(1607 sentences)


73255 reads, 512 reads per million, 82 experiments

c u   u  AG             UCA     -ac   c  cg 
 g ugc gc  CUGGUGUUGUGAA   GGCCG   gag ag  c
 | ||| ||  |||||||||||||   |||||   ||| ||   
 c acg UG  GACCACAGCACUU   UCGgc   uuc uc  a
a u   U  -G             -UA     cca   -  cu 

Annotation confidence High
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The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr16: 56858518-56858601 [+]

Disease association
hsa-mir-138-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-138-5p

Accession MIMAT0000430
Description Homo sapiens hsa-miR-138-5p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-138-2-3p

Accession MIMAT0004596
Description Homo sapiens hsa-miR-138-2-3p mature miRNA
Evidence experimental
cloned [2]


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739