Accession
MI0000459
Symbol
HGNC:
MIR143
Description
Homo sapiens
hsa-mir-143 precursor miRNA mir-143
Gene
family?
family?
RF00683;
mir-143
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR143 is a microRNA that plays a significant role in the regulation of various cellular processes, such as inflammation and apoptosis, particularly in the context of obesity [PMC9687157]. Studies have identified a negative correlation between the levels of MIR143 and the mRNA of pro-inflammatory cytokines like IL1β, IL6, and TNFα in the ovaries of obese individuals [PMC9687157]. This correlation suggests that MIR143 could be involved in the modulation of inflammatory responses that are associated with obesity [PMC9687157]. Moreover, the over-expression of MIR143 has been associated with a decrease in the expression of its predicted target proteins, which include hexokinase 2 (HK2) and the beta-1 adrenergic receptor (ADRB1) [PMC5735881]. These target proteins are known to be involved in metabolic pathways and the cellular response to stress [PMC5735881]. Additionally, an increase in MIR143 levels leads to a lower Bcl-2/Bax ratio, which is indicative of its potential impact on the mechanisms of apoptosis [PMC5735881]. Taken together, these findings suggest that MIR143 could have therapeutic relevance for the treatment of obesity-related inflammation and the metabolic disturbances that accompany it [PMC5735881; PMC9687157]..
Literature search
482 open access papers mention hsa-mir-143
(3462 sentences)
(3462 sentences)
Sequence
11084797
reads,
27646
reads per million, 158 experiments
gcgcagcgcccugucucccagccugaGGUGCAGUGCUGCAUCUCUGGUcaguugggagucUGAGAUGAAGCACUGUAGCUCaggaagagagaaguuguucugcagc
((((((.((....((((.(..((((((.(((((((((.((((((.((((......)).)).)))))).))))))))).))))))..).))))....)).)))).))
((((((.((....((((.(..((((((.(((((((((.((((((.((((......)).)).)))))).))))))))).))))))..).))))....)).)))).))
Structure
- c ccug c ag G G U - ag gc gcag gc ucuc c ccugaG UGCAGUGCU CAUCUC GG Uc u || |||| || |||| | |||||| ||||||||| |||||| || || cg cguc ug agag g ggaCUC AUGUCACGA GUAGAG cu ag u a u uuga a aa G A U g gg
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-143 in human, and demonstrated significantly reduced levels of the miRNA in precancerous and neoplastic colorectal tissue [2]. miR-143 cloned in [3] has a 1 nt 3' extension (A), which is incompatible with the genome sequence.
Genome context
chr5: 149428918-149429023 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-143
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-143 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-143-5p
| Accession | MIMAT0004599 |
| Description | Homo sapiens hsa-miR-143-5p mature miRNA |
| Sequence | 27 - GGUGCAGUGCUGCAUCUCUGGU - 48 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-143-3p
| Accession | MIMAT0000435 |
| Description | Homo sapiens hsa-miR-143-3p mature miRNA |
| Sequence | 61 - UGAGAUGAAGCACUGUAGCUC - 81 |
| Evidence |
experimental
cloned [2-3], Illumina [4] |
| Database links |
|
| Predicted targets |
|
References
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