miRBase entry: hsa-mir-143

Stem-loop hsa-mir-143

Homo sapiens hsa-mir-143 precursor miRNA
Gene family
MIPF0000094; mir-143

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR143 is a microRNA that has been studied in the context of obesity and ovarian function [PMC9687157]. In a study, it was found that the levels of MIR143 were negatively correlated with the mRNA levels of inflammatory cytokines IL1β, IL6, and TNFα in the ovaries of obese individuals [PMC9687157]. This suggests that MIR143 may play a role in regulating inflammation in obese individuals. Additionally, over-expression of MIR143 led to decreased expression of predicted target proteins HK2 and ADRB1, as well as a reduced Bcl-2/Bax ratio [PMC5735881]. This indicates that MIR143 may also be involved in regulating cellular metabolism and apoptosis. These findings highlight the potential importance of MIR143 in obesity-related ovarian dysfunction and provide insights into its molecular mechanisms [PMC9687157] [PMC5735881]. Further research is needed to fully understand the role of MIR143 in these processes and its potential as a therapeutic target for obesity-related disorders [PMC9687157] [PMC5735881].

Literature search
482 open access papers mention hsa-mir-143
(3462 sentences)


11084797 reads, 27646 reads per million, 158 experiments

  -    c  ccug    c ag      G         G      U  -  ag 
gc gcag gc    ucuc c  ccugaG UGCAGUGCU CAUCUC GG Uc  u
|| |||| ||    |||| |  |||||| ||||||||| |||||| || ||   
cg cguc ug    agag g  ggaCUC AUGUCACGA GUAGAG cu ag  u
  a    u  uuga    a aa      G         A      U  g  gg 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-143 in human, and demonstrated significantly reduced levels of the miRNA in precancerous and neoplastic colorectal tissue [2]. miR-143 cloned in [3] has a 1 nt 3' extension (A), which is incompatible with the genome sequence.

Genome context
chr5: 149428918-149429023 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-143
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-143 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-143-5p

Accession MIMAT0004599
Description Homo sapiens hsa-miR-143-5p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets

Mature hsa-miR-143-3p

Accession MIMAT0000435
Description Homo sapiens hsa-miR-143-3p mature miRNA
Evidence experimental
cloned [2-3], Illumina [4]
Database links
Predicted targets


  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  4. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739