Stem-loop hsa-mir-138-1

Accession

MI0000476

Symbol

HGNC: MIR138-1

Description

Homo sapiens hsa-mir-138-1 precursor miRNA mir-138

Gene
family

RF00671; mir-138

Literature search

228 open access papers mention hsa-mir-138-1
(1564 sentences)

Sequence

87542 reads, 366 reads per million, 82 experiments

cccuggcauggugugguggggcAGCUGGUGUUGUGAAUCAGGCCGuugccaaucagagaacgGCUACUUCACAACACCAGGGCCacaccacacuacagg
.((((...((((((((((.(((..(((((((((((((...(((((((..(.....)..)))))))..))))))))))))).))).))))))))))))))

Structure

c    gca          g   AG             UCA       gc a 
 ccug   ugguguggug ggc  CUGGUGUUGUGAA   GGCCGuu  c a
 ||||   |||||||||| |||  |||||||||||||   |||||||  | u
 ggac   aucacaccac CCG  GACCACAACACUU   UCGgcaa  g c
-    ---          a   -G             -CA       ga a 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Expression in human was later validated by cloning [2].

Genome context

chr3: 44114212-44114310 [+]

Disease association

hsa-mir-138-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-138-5p

• Accession: MIMAT0000430
• Description: Homo sapiens hsa-miR-138-5p mature miRNA
• Sequence: 23 - AGCUGGUGUUGUGAAUCAGGCCG - 45
• Evidence: experimental ; cloned [2]

Mature hsa-miR-138-1-3p

• Accession: MIMAT0004607
• Description: Homo sapiens hsa-miR-138-1-3p mature miRNA
• Sequence: 63 - GCUACUUCACAACACCAGGGCC - 84
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043