Accession
MI0000478
Symbol
HGNC:
MIR149
Description
Homo sapiens
hsa-mir-149 precursor miRNA mir-149
Gene
family?
family?
RF00829;
mir-149
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR149 is a gene that is situated on chromosome 2 at the 2q37.3 locus and is characterized by a single exon responsible for coding the miR-149 microRNA [PMC9956572]. This gene has been observed to exhibit polymorphisms, which suggests a potential for variability in its function or expression [PMC9956572]. However, the specific mechanisms by which MIR149 modulates the expression of matrix metalloproteinases (MMPs) and cyclin D remain unclear and have been identified as an important area for future research endeavors [PMC5983960]. The influence of MIR149 on the expression of the EphB3 gene in certain colorectal cancer cell lines, such as SW1116 and HCT116, has been noted, but the statement regarding the influence of "Form" is not supported by the provided references and therefore has been omitted from this summary.
Literature search
114 open access papers mention hsa-mir-149
(820 sentences)
(820 sentences)
Sequence
41611
reads,
225
reads per million, 121 experiments
gccggcgcccgagcUCUGGCUCCGUGUCUUCACUCCCgugcuuguccgaggagggAGGGAGGGACGGGGGCUGUGCuggggcagcugga
.(((((((((.(((.(.(.((((((.(((((.(((((.(.(((....))).))))))))))).)))))).).).))).)))).))))).
.(((((((((.(((.(.(.((((((.(((((.(((((.(.(((....))).))))))))))).)))))).).).))).)))).))))).
Structure
g - g U U G G A g g g ccggc gccc agc C G CUCCGU UCUUC CUCCC u cuu u ||||| |||| ||| | | |||||| ||||| ||||| | ||| ggucg cggg uCG G C GGGGCA GGAGG GAggg a gag c a a g U U G G - - g c
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr2: 240456001-240456089 [+]
Disease association
hsa-mir-149 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-149-5p
| Accession | MIMAT0000450 |
| Description | Homo sapiens hsa-miR-149-5p mature miRNA |
| Sequence | 15 - UCUGGCUCCGUGUCUUCACUCCC - 37 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-149-3p
| Accession | MIMAT0004609 |
| Description | Homo sapiens hsa-miR-149-3p mature miRNA |
| Sequence | 56 - AGGGAGGGACGGGGGCUGUGC - 76 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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