miRBase entry: hsa-mir-193a

Stem-loop hsa-mir-193a

Homo sapiens hsa-mir-193a precursor miRNA
Gene family
MIPF0000082; mir-193

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR193A is a microRNA that has been studied in various diseases, including primary focal segmental glomerulosclerosis (FSGS), minimal change disease, and hepatocellular carcinoma (HCC) [PMC9953542] [PMC7226544] [PMC9562882]. In primary FSGS, MIR193A is found to be overexpressed in podocytes, while genetic FSGS and minimal change disease exhibit low levels of MIR193A similar to normal kidneys [PMC9953542]. This suggests a potential causal relationship between the expression of the vitamin D receptor/retinoid X receptor (VDR/RXR) and the downregulation of MIR193A in these diseases [PMC7226544]. In breast cancer cells, overexpression of MIR193A inhibits micro-vessel formation by 40% compared to control cells [PMC9562882]. The expression levels of MIR193A by precursor progenitor cells determine their net phenotype as either podocytes or parietal epithelial cells through modulation of WT1 gene expression [PMC9953542]. The position of the 3' untranslated region (UTR) plays a significant role in miRNA activity, with an ideal distance from the stop codon or seed location for optimal MIR193A activity [PMC7226544]. In HCC, downregulation of miR-23b and MIR193A may contribute to disease diagnosis and miR-193a could be a prognostic factor for HCC patients. DNA methylation mediates miR-23b expression but not miR-193a in primary HCC [PMC5351682]. Transcription factors such as YY1, WT1, and Sox2 may regulate MIR193A expression by binding to its promoter region. Additionally, exosomes secreted by advanced mouse colon cancer cells contain MIR193A, a tumor suppressor miRNA, along with MVP [PMC7916137]. MIR193A has also been suggested to bind to the mRNA of the APOL1 3' UTR region, and the expression of APOL1 in podocytes is associated with the regulation of MIR193A and actin cytoskeleton organization [PMC7226544] [PMC8391400].

Literature search
148 open access papers mention hsa-mir-193a
(1073 sentences)


88892 reads, 1104 reads per million, 159 experiments

cgaggau   a             U     C    G  A   gggu 
       ggg gcugagggcUGGG CUUUG GGGC AG UGA    g
       ||| ||||||||||||| ||||| |||| || |||     
       ccc cggcucuUGACCC GAAAC UCCG UC Acu    u
------g   c             U     A    G  A   aggc 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context
chr17: 31559996-31560083 [+]

Disease association
hsa-mir-193a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-193a-5p

Accession MIMAT0004614
Description Homo sapiens hsa-miR-193a-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-193a-3p

Accession MIMAT0000459
Description Homo sapiens hsa-miR-193a-3p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179